From Journal of Clinical Investigation
JCI table of contents, May 15, 2003
Approximately half of all individuals implanted with pacemakers suffer from sinus node dysfunction. A new study of one such patient reveals a previously unknown mutation in the gene thought to primarily regulate the rhythmicity of the beating heart.
TITLE: Pacemaker channel dysfunction in a patient with sinus node disease
Department of Cardiology, Hospital of the University of Münster, Münster, Germany.
View the PDF of this article at: https://www.the-jci.org/press/16750.pdf
Throwing lupus for a loop
Lupus, an autoimmune disease primarily affecting women of childbearing age, is treated with steroids that often leave patients susceptible to infections, diabetes, and high blood pressure. A new study in non-human primates reports that treatment with specific antibodies can reverse established disease without the side effects associated with current steroid-based therapies.
TITLE: CD137 costimulatory T cell receptor engagement reverses acute disease in NZB x NZW F1 lupus-prone mice
Emory University School of Medicine, Atlanta, Georgia, USA.
View the PDF of this article at: https://www.the-jci.org/press/17662.pdf
Programmed death of cardiac cells can cause heart failure
TITLE: A mechanistic role for cardiac myocyte apoptosis in heart failure
Albert Einstein College Of Medicine, Bronx, New York, USA.
Phone 1: 718-430-2609
Phone 2: 718-430-2000
View the PDF of this article at: https://www.the-jci.org/press/17664.pdf
TITLE: Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
New Jersey Medical School and Hackensack University Medical Center, Newark, New Jersey, USA.
View the PDF of this article at: https://www.the-jci.org/press/17459.pdf
A matter of life and death: cardiac myocyte apoptosis and regeneration
New York Medical College, Valhalla, New York, USA.
View the PDF of this commentary at: https://www.the-jci.org/press/18611.pdf
Host proteins prove to be antibactericidal all on their own
TITLE: Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability.
Francis X. McCormack
University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
View the PDF of this article at: https://www.the-jci.org/press/16889.pdf
Pulmonary surfactant: a front line of lung host defense
Jo Rae Wright
Duke University School Of Medicine, Durham, North Carolina, USA.
View the PDF of this commentary at: https://www.the-jci.org/press/18650.pdf
CD44's role in allergic airway inflammation and asthma
TITLE: A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia
Miyazaki Medical College, Kiyotake, Myazaki, Japan
View the PDF of this article at: https://www.the-jci.org/press/16583.pdf
CD44 -- a sticky target for asthma
Marc E. Rothenberg
Children's Hospital Medical Center, Cincinnati, Ohio, USA.
View the PDF of this commentary at: https://www.the-jci.org/press/18392.pdf
New path to therapy for pulmonary hypertension
Current treatments for pulmonary hypertension are only capable of delaying progression of the disease and lung transplantation is ultimately necessary. Researchers have now found that mice deficient of a factor known as HIF-2a are protected against pulmonary hypertension, indicating that pharmaceutical inhibitors of this factor may be useful in the prevention or reduction of pulmonary hypertension.
TITLE: Heterozygous deficiency of hypoxia-inducible factor-2a protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
KU Leuven, Flanders Interuniversity Institute of Biotechnology, Leuven, Belgium.
Phone 1: 32-16-345-772
Phone 2: 32-16-345-780
View the PDF of this article at: https://www.the-jci.org/press/15496.pdf
At the heart of hypertrophy
TITLE: Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling
Jeffrey D. Molkentin
Children's Hospital Medical Center, Cincinnati, Ohio, USA.
View the PDF of this article at: https://www.the-jci.org/press/17295.pdf
Alternative strategy for tumor immunotherapy
TITLE: Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes
Ohio State University Medical Center, Columbus, Ohio, USA.
View the PDF of this article at: https://www.the-jci.org/press/17656.pdf
Cardiac muscle gets excited
TITLE: Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression
University of Maryland School of Medicine, Baltimore, Maryland, USA.
View the PDF of this article at: https://www.the-jci.org/press/17959.pdf
Distinguishing self from non-self in transplant rejection
TITLE: Critical role of Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
Yale University, New Haven, Connecticut, USA.
View the PDF of this article at: https://www.the-jci.org/press/17573.pdf
The cardiovascular effects of cholesterol carriers and estrogen
TITLE: HDL-associated estradiol stimulates endothelial NO synthase and vasodilation in an SR-BI–dependent manner
University of Kentucky, Lexington, Kentucky, USA.
View the PDF of this article at: https://www.the-jci.org/press/16777.pdf
Glucose sensing and signaling
TITLE: GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor–stimulated muscle glucose utilization
University Of Lausanne, Lausanne, Switzerland.
View the PDF of this article at: https://www.the-jci.org/press/16888.pdf
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