December 2002
From Royal Society of Chemistry
Organic & Biomolecular Chemistry The first issue of Organic & Biomolecular Chemistry, formed from the merger and strategic development of Perkin Transactions 1 & 2, will be published on 10 January 2003. The electronic version will go up on 23 December 2002.Barbara Imperiali, Francois Diederich, Ben Feringa and Chi-Huey Wong are amongst the first eminent scientists to publish Advance Articles in the journal. Further details are given below. The first issue will also feature contributions from Steve Ley, Jay Siegel and Michael Burkart, these will be available online soon. Advance Articles Now Available on the Journal Website Include:- Perspective
HIV-1 Protease: Mechanism and Drug Discovery
Chi-Huey Wong, Scripps, USA Communications
A donor-acceptor substituted molecular motor: unidirectional rotation driven by visible light.
Ben Feringa, Groningen, The NetherlandsA new synthesis of porphobilinogen analogues, inhibitors of hydroxymethylbilane synthase
Finian Leeper, Cambridge, UK Non-steady-state kinetic study of the SN2 reaction between p-nitrophenoxide ion and methyl iodide in aprotic solvents containing water. Evidence for a 2-step mechanism.
Vernon D. Parker, Utah State, USA Facilitated transport of sodium or potassium chloride across vesicle membranes using a ditopic salt-binding macrobicycle
Bradley D. Smith, Notre Dame, USA From central to planar chirality, the first example of atropenantioselective cycloetherification
Jieping Zhu, CNRS, France Articles Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity
François Diederich, ETH, SwitzerlandPeptides to peptidomimetics: Towards the design and synthesis of bioavailable inhibitors of oligosaccharyl transferase
Barbara Imperiali, MIT, USA Synthesis of novel chiral phosphinocyrhetrenyloxazoline ligands and their application in asymmetric catalysis
Carsten Bolm, Aachen, Germany Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes
John Vederas, Alberta, Canada Organic & Biomolecular Chemistry will be an essential read for organic chemists. The new journal has attracted contributions from a great number of leading institutions all over the world on topics covering the full breadth of organic chemistry. These are exciting times for organic chemists, who are at the molecular heart of life science. Synthetic and physical organic chemistry are rapidly gaining importance in the emerging fields of chemical biology and nanotechnology where they play a crucial role in the development of new bioactive substances and novel materials. Organic & Biomolecular Chemistry will be key to the dissemination of these advances. | 