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Gut ecology in transplant patients

Small-bowel transplant patients with an ileostomy -- an opening into their small bowel -- have a very different population of bacteria living in their gut than patients whose ileostomy has been closed, researchers from UC Davis and Georgetown University Medical Center have found. The results are published online Sept. 14 in the Proceedings of the National Academy of Sciences.

Transplanted human stem cells prolong survival in mouse model of rare brain disease

A new study finds substantial improvement in a mouse model of a rare, hereditary neurodegenerative disease after transplantation of normal human neural stem cells.

Study results promise faster recovery from life-threatening blood cell shortages

A key compound resupplies bone marrow with fast-acting stem cells that can more quickly rekindle blood cell production, according to a study published online today in the journal Blood. While the study was in mice, in the study authors say it has the potential to increase survival among patients with life-threatening blood cell shortages.

A breath of fresh air could improve drug toxicity screening

A team led by Massachusetts General Hospital (MGH) researchers has developed an innovative way to culture liver cells for drug toxicity screening.

Progress made in traumatic brain injury treatment and diagnosis

KANSAS CITY, MO -- September 1, 2009 -- New research on traumatic brain injury (TBI) is being presented this week at the Military Health Research Forum (MHRF), a scientific meeting hosted by the Department of Defense (DOD) Congressionally Directed Medical Research Programs (CDMRP). Service men and women are particularly susceptible to TBI given the nature of combat.

Gene signal GS-101 data shows safe and effective inhibition of ophthalmic blood vessel growth

Lausanne, Switzerland -- Gene Signal, a company focused on developing innovative drugs to manage angiogenesis based conditions, today announced the publication of interim results from a phase II study suggesting that the antisense oligonucleotide GS-101 (eye drops) is safe and effective at inhibiting and regressing corneal neovascularisation (abnormal new blood vessel growth).

Women, blacks, Medicare recipients less likely to be evaluated for liver transplantation

PITTSBURGH, Aug. 31 -- Patient race, gender and insurance status influence decisions about who will go on to receive liver transplants, according to a University of Pittsburgh School of Medicine study.

New European guidelines on pulmonary hypertension provide new 6-group clinical definition

Barcelona, Spain, 31 August: New 2009 Guidelines for the diagnosis and treatment of pulmonary hypertension are made public today. The Guidelines have been jointly produced by a Task Force of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS); the Task Force also included experts from the International Society of Heart and Lung Transplantation (ISHLT).

UF scientists construct 'off switch' for Parkinson therapy

GAINESVILLE -- A common antibiotic can function as an "off switch" for a gene therapy being developed for Parkinson's disease, according to University of Florida researchers writing online in advance of September's Molecular Therapy.

Researchers find high-dose therapy for liver disease not effective

ROCHESTER, Minn. -- A national team of researchers led by scientists at Mayo Clinic has found that a common treatment for primary sclerosing cholangitis, a chronic liver disease, is not helpful for patients, according to a study published this month in the journal Hepatology.

Racial disparity studied in patients undergoing liver transplantation for hepatitis B

According to the Centers for Disease Control and Prevention (CDC) 1.5 to 2 million Americans are infected with the hepatitis B virus (HBV). Prior studies have shown there to be significant racial differences in access to and outcomes of liver transplantation. Recently, doctors from across the U.S.

Turning back the clock: Fasting prolongs reproductive life span

SEATTLE -- Scientific dogma has long asserted that females are born with their entire lifetime's supply of eggs, and once they're gone, they're gone. New findings by researchers at Fred Hutchinson Cancer Research Center, published online Aug.

Study finds promise in combined transplant/vaccine therapy for high-risk leukemia

BOSTON--Two of the most powerful approaches to cancer treatment -- a stem cell transplant and an immune system-stimulating vaccine -- appear to reinforce each other in patients with an aggressive, hard-to-control form of leukemia, Dana-Farber Cancer Institute scientists have found.

Still holding their breath: Mortality on lung transplant wait list remains high for some

Mortality remains high among patients with pulmonary arterial hypertension awaiting lung transplant, despite changes to the allocation system that were designed to reduce mortality and increase the equitable distribution of donor organs, according to new research out of University of California San Francisco.

Increasing the number of kidney transplants

In most transplant centers, the kidneys of very young deceased donors are transplanted together into one patient. According to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), a single kidney from a very young deceased donor maintains the health of an adult with kidney failure.



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