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Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

PHILADELPHIA -- Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months, according to a report in Cancer Research, a journal of the American Association for Cancer Research.

A crystal ball for brain cancer?

UCLA researchers have uncovered a new way to scan brain tumors and predict which ones will be shrunk by the drug Avastin -- before the patient ever starts treatment. By linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy.

Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report

DALLAS -- July 30, 2009 -- The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.

EphA2-targeted therapy delivers chemo directly to ovarian cancer cells

HOUSTON - With a novel therapeutic delivery system, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center has successfully targeted a protein that is over-expressed in ovarian cancer cells.

Low prevalence of HPV infection may be tied to poor prognosis for blacks with head and neck cancer

Researchers at the University of Maryland Marlene and Stewart Greenebaum Cancer have found that head and neck cancer patients who test positive for the human papillomavirus (HPV) have much better survival rates than patients who don't have the virus, according to a new study in the journal Cancer Prevention Research. The researchers also discovered that blacks in the study had a very low

New drug for children with high-risk leukemia

Each year, approximately 4,500 children in America are diagnosed with leukemia, according to the Leukemia and Lymphoma Society. A potentially deadly cancer of the blood, it is the most common cancer in children.

'Corrective genes' closer thanks to enzyme modification

Scientists from the Université de Montréal and McGill University have re-engineered a human enzyme, a protein that accelerates chemical reactions within the human body, to become highly resistant to harmful agents such as chemotherapy, according to a new study published in The Journal of Biological Chemistry.

Genetic testing may be valuable in treating colorectal cancer

NEW YORK (July 27, 2009) -- For the 29,000 patients in the United States with metastatic colorectal cancer, chemotherapy with irinotecan is a standard treatment that has been shown to improve survival.

Surgery remans an option for advanced lung cancer

MAYWOOD, Il. -- In recent years, oncologists have debated whether patients with a certain type of advanced lung cancer would benefit from surgery.

Stripping leukemia-initiating cells of their 'invisibility cloak'

Two new studies reveal a way to increase the body's appetite for gobbling up the cancer stem cells responsible for acute myeloid leukemia (AML), a form of cancer with a particularly poor survival rate.

Study provides documentation that tumor 'stem-like cells' exist in benign tumors

LOS ANGELES (July 22, 2009) -- Cancer stem-like cells have been implicated in the genesis of a variety of malignant cancers. Research scientists at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute have isolated stem-like cells in benign (pituitary) tumors and used these "mother" cells to generate new tumors in laboratory mice.

Life after chemotherapy: Daily tasks, quality of life may be affected, MU researcher finds

COLUMBIA, Mo. - Each day, thousands of people undergo chemotherapy treatments for different types of cancer, and it is widely known that patients are negatively affected during the treatments; previous research has shown decreases in cognitive functioning among cancer survivors following treatment.

Researchers identify genes linked to chemoresistance

RICHMOND, Va. (July 20, 2009) -- Two genes may contribute to chemotherapy resistance in drugs like 5-fluorouracil, which is used in liver cancer treatment, according to Virginia Commonwealth University Massey Cancer Center researchers.

Laser microsurgery for tongue cancer is as effective as invasive open surgery according to new study

CHICAGO -- Transoral (through-the-mouth) laser surgery to remove cancer at the base of the tongue is as effective as more invasive open surgery and may improve quality of life according to a new study by Rush University Medical Center. The study is published in the July issue of the scientific journal Otolaryngology ?Head and Neck Surgery.

Studies shed light on preserving fertility among cancer patients

PITTSBURGH, July 20 -- Cancer treatment has come a long way, leading to a multitude of therapy options and improved survival rates. These successes, however, have created a challenge for young cancer patients since chemotherapy and radiation treatments that often save lives threaten fertility.



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