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STAT3 gene regulates cancer stem cells in brain cancer

BOSTON (August 10, 2009) -- In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation.

Tumor mutations can predict chemo success

New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.

Decoding leukemia patient genome leads scientists to mutations in other patients

Decoding the complete DNA of cancer patients is giving scientists at Washington University School of Medicine in St. Louis a clearer picture of the complexity of the disease and allowing them to see intriguing and unexpected genetic relationships among patients.

Sensitizing tumor response to cancer therapy

Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.

Nanoparticles cross blood-brain barrier to enable 'brain tumor painting'

Brain cancer is among the deadliest of cancers. It's also one of the hardest to treat. Imaging results are often imprecise because brain cancers are extremely invasive. Surgeons must saw through the skull and safely remove as much of the tumor as they can.

Multimodality treatments effective in halting lung cancer progression

SAN FRANCISCO, August 3, 2009 -- The world?s top lung cancer specialists, medical professionals and researchers are convening this week in San Francisco, CA for the 13th World Conference on Lung Cancer (WCLC), organized by the International Association for the Study of Lung Cancer (IASLC).

PET can help guide treatment decisions for a common pediatric cancer

RESTON, Va. -- A new study published in the August issue of The Journal of Nuclear Medicine shows that positron emission tomography (PET) is an important tool for depicting the extent of neuroblastoma in some patients, particularly for those in the early stages of the disease.

Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients

SAN FRANCISCO (August 1, 2009) -- Previously untreated non-small cell lung cancer (NSCLC) patients over the age of 70 respond well to a combination of bevacizumab and erlotinib, Fox Chase Cancer Center researchers reported today at the annual meeting of the International Association for the Study of Lung Cancer.

Advanced targeted therapies effective as first-line treatment for lung cancer

SAN FRANCISCO, August 1, 2009 -- The world's top lung cancer specialists, medical professionals and researchers are convening this week in San Francisco, CA for the 13th World Conference on Lung Cancer (WCLC), organized by the International Association for the Study of Lung Cancer (IASLC).

MIT team targets ovarian cancer with nanoparticles

CAMBRIDGE, Mass. -- Tiny particles carrying a killer gene can effectively suppress ovarian tumor growth in mice, according to a team of researchers from MIT and the Lankenau Institute.

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

PHILADELPHIA -- Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months, according to a report in Cancer Research, a journal of the American Association for Cancer Research.

A crystal ball for brain cancer?

UCLA researchers have uncovered a new way to scan brain tumors and predict which ones will be shrunk by the drug Avastin -- before the patient ever starts treatment. By linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy.

Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report

DALLAS -- July 30, 2009 -- The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.

EphA2-targeted therapy delivers chemo directly to ovarian cancer cells

HOUSTON - With a novel therapeutic delivery system, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center has successfully targeted a protein that is over-expressed in ovarian cancer cells.



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