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Researchers induce HIV-neutralizing antibodies that recognize HIV-1 envelope protein, lipids

(Rockville, MD) -- For the first time, researchers have experimentally induced antibodies that neutralize HIV-1 and simultaneously recognize both HIV-1 envelope protein and lipids. The results were reported by U.S. Military HIV Research Program (MHRP) researchers on Aug. 25 in the online version of AIDS, the official journal of the International AIDS Society.

Prodrug could help curb skin toxicity related to EGFR-inhibiting cancer drugs

(PHILADELPHIA) There may be a way around the harsh skin toxicity associated with a widely used cancer drug, according to a study published online this week in Cancer Biology and Therapy by researchers from City of Hope and the Kimmel Cancer at Jefferson.

Gene signal GS-101 data shows safe and effective inhibition of ophthalmic blood vessel growth

Lausanne, Switzerland -- Gene Signal, a company focused on developing innovative drugs to manage angiogenesis based conditions, today announced the publication of interim results from a phase II study suggesting that the antisense oligonucleotide GS-101 (eye drops) is safe and effective at inhibiting and regressing corneal neovascularisation (abnormal new blood vessel growth).

Princeton team learns why some drugs pack such a punch

By studying the intricate mechanisms at work in protein production, a Princeton-led team has discovered why certain kinds of antibiotics are so effective. In doing so, they also have discovered how one protein protects against cell death, shedding light on a natural cancer-fighting process.

Key feature of immune system survived in humans, other primates for 60 million years

CORVALLIS, Ore. -- A new study has concluded that one key part of the immune system, the ability of vitamin D to regulate anti-bactericidal proteins, is so important that is has been conserved through almost 60 million years of evolution and is shared only by primates, including humans -- but no other known animal species.

Milk is safe, even encouraged, for some children after treatment for milk allergy

Some children with a history of severe milk allergy can safely drink milk and consume other dairy products every day, according to research led by the Johns Hopkins Children's Center and published in the Aug. 10 online edition of the Journal of Allergy and Clinical Immunology.

Pitt researchers harness carbon nanomaterials for drug delivery systems, oxygen sensors

PITTSBURGH -- Two nanoscale devices recently reported by University of Pittsburgh researchers in two separate journals harness the potential of carbon nanomaterials to enhance technologies for drug or imaging agent delivery and energy storage systems, in one case, and, in the other, bolster the sensitivity of oxygen sensors essential in confined settings, from mines to spacecrafts.

Mother's immune system may block fetal treatments for blood diseases

Pediatric researchers have resolved an apparent contradiction in the field of prenatal cell transplantation -- a medical approach that holds future promise in correcting sickle cell disease and other serious congenital blood disorders.

Budesonide is not beneficial for the treatment of diarrhea in metastatic melanoma patients

PHILADELPHIA -- Patients with stage III or IV melanoma taking ipilimumab and the oral steroid budesonide to reduce side effects did not have less diarrhea, a known side effect of ipilimumab, according to results of a phase II trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Antibodies to strep throat bacteria linked to obsessive compulsive disorder in mice

August 11, 2009, New York, NY -- A new study by researchers at Columbia University Mailman School of Public Health's Center for Infection and Immunity indicates that pediatric obsessive-compulsive disorder (OCD), Tourette syndrome and/or tic disorder may develop from an inappropriate immune response to the bacteria causing common throat infections.

Potential risk identified in transfusions of platelets before bone marrow transplant

Research on blood transfusions points to a potential risk of transfusing donated platelets, especially to patients with bone marrow failure syndromes who are subsequently candidates for bone marrow transplantation.

The results are online and scheduled for publication in the September 1 issue of the Journal of Clinical Investigation.

Yerkes researchers propose ambitious new strategies for AIDS vaccine research

Researchers at the Yerkes National Primate Research Center, Emory University, believe conventional vaccine strategies should not be the only avenue explored in the development of an effective AIDS vaccine.

First human gets new antibody aimed at hepatitis C virus

Boston, Mass. -- Building upon a series of successful preclinical studies, researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) today announced the beginning of a Phase 1 clinical trial, testing the safety and activity of a human monoclonal antibody they developed that can neutralize the Hepatitis C virus (HCV).

Cyber exploring the 'ecosystems' of influenzas

ALBUQUERQUE, N.M. -- Predicting the infection patterns of influenzas requires tracking both the ecology and the evolution of the fast-morphing viruses that cause them, said a Duke University researcher who enlists computers to model such changes.

On the move

La Jolla, CA -- Rather than sticking to a single DNA script, human brain cells harbor astonishing genomic variability, according to scientists at the Salk Institute for Biological Studies. The findings, to be published in the Aug.



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