Michigan
While past research has connected oral malodor to the proliferation of certain bacteria on the tongue, recent research from the Forsyth Institute and the University of Michigan School of Dentistry indicates another group of bacteria is associated with fresh-smelling breath. Investigators used gene sequencing to compare bacteria found on the tongues of individuals with halitosis and those with fresh breath. While not all samples taken from halitosis sufferers had the same bacterial makeup, three particular strains -- Streptococcus salivarius, Rothia mucilaginosa and a previously uncharacterized strain of Eubacterium -- were the most prevalent species on the tongues of subjects with fresh breath.
A common genetic variant influences individual responses and adaptation to pain and other stressful stimuli and may underlie vulnerability to many psychiatric and other complex diseases, reports David Goldman, M.D., Chief, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, and colleagues at NIAAA and the University of Michigan. COMT val158met Genotype Affects m-Opioid Neurotransmitter Responses to a Pain Stressor appears in the February 21 issue of Science.
The largest-ever study of cocaine users who suffered heart-related effects from taking the drug finds that a specially designed plan of emergency-room care for such patients can save both lives and money. Such plans have been in place for traditional chest pain patients for years, and many hospitals set aside part of their ERs to hold them for observation. But doctors have lacked criteria to help them decide how long to hold patients whose chest pain was caused by cocaine - even as millions of Americans are using the drug.
An ongoing national shortage of a vaccine that prevents meningitis and pneumonia in children has left doctors scrambling to provide even the minimum number of shots, and has exposed gaps in the nation's "patchwork" vaccine system, the first-ever in-depth study of the problem finds.
The quest for a fashion model's figure leads many girls and women to a cycle of weight loss and weight gain called yo-yo dieting. Some women never succeed in achieving or maintaining their desired weight, although some do. Researchers at the VA/Ann Arbor Healthcare System and the University of Michigan Health System are cautioning all women who yo-yo diet. Those who gain and/or lose at least 10 pounds in a yearlong period at least five times over a lifetime may be setting themselves up for heart problems after menopause.
Wetlands in the Midwest? It may be hard to believe but vast areas of today's Corn Belt used to get so wet that malaria was common. While the remaining wetlands are small and scattered, there's still hope -- new research shows that most of the original species may still survive.
"We often look to other regions of the world as biodiversity hotspots but it is worth noting that some of the most heavily impacted regions ? such as the Corn Belt ? should not be written off as biodiversity wastelands," says David Jenkins of the University of Illinois at Springfield, who presents this work with Scott Grissom of Grand Valley State University in Allendale, Michigan, and Keith Miller of the University of Illinois at Springfield in the February issue of Conservation Biology.
Patients who develop melanoma on their face, head or neck can have the same early-diagnosis surgical procedure to see if their cancer might spread as patients whose cancer is on less delicate areas of the body, a new study finds. The report, from a team at the University of Michigan Comprehensive Cancer Center, opens the door for many more melanoma patients to benefit from a potentially life-saving technique called sentinel lymph node mapping. The results will be published in the Archives of Otolaryngology, a journal of the American Medical Association.
Despite widespread warnings about the potential risk of drinking alcohol during pregnancy, fifteen percent of pregnant women in a newly published study said they had drunk alcohol at least once during their pregnancies. And although most of those women reported on an anonymous survey that they'd had less than one drink a week, some acknowledged drinking more than that on a regular basis, or said they'd had at least one binge of five or more drinks at once.
Overweight and obese individuals incur up to $1,500 more in annual medical costs than healthy-weight individuals, according to a two-year study of nearly 200,000 employees of General Motors. Average annual medical costs for normal weight individuals in the study were $2,225, while costs for overweight and obese individuals rose steadily, from $2,388 for overweight individuals to $3,753 for the most severely obese persons. The study, by Dee W. Edington, Ph.D., of the University of Michigan and colleagues, is the first to examine the relationship between medical costs and the six weight groups defined by the National Heart, Lung and Blood Institute's weight guidelines. The guidelines separate individuals into categories of underweight, healthy-weight, overweight and three different obesity designations, based on average body mass index.
The process that makes fireflies glow bright in the summer night can also shed light on how well new medicines work, showing immediately whether the drugs are effective at killing cells or causing other effects. That's the conclusion of a team of scientists who report that they have inserted the gene for a firefly's glow-producing molecule into mice with cancer, and kept it from producing its telltale beacon of light until the cells started to die in response to cancer treatment.
This year's annual Monitoring the Future survey of American secondary school students provides much good news for the nation, reports the University of Michigan. Ecstasy use is finally beginning to decline among adolescents, the proportion using any illicit drug is also down, the proportion drinking alcohol has dropped, and the proportion reporting cigarette smoking continues to drop sharply.
The first direct evidence that muscle cells transplanted from within a heart patient's body could help heal their damaged heart muscle is being reported today. In the study, a small sample of cells from patients' thigh muscles were taken, and "satellite" myoblast cells were isolated and grown in culture until they multiplied. These cells were then injected into the hearts of four patients who were receiving heart-assisting implants to help them survive until they could get a heart transplant. The results showed that the injected cells not only survived in their new environment, but began to form muscle fibers.
Researchers say the biological motors that nature uses for intracellular transport and other biological functions inspired them to create a whole new class of micro-devices for controlling magnetic flux quanta in superconductors that could lead to the development of a new generation of medical diagnostic tools. As integrated circuits become smaller and smaller, it becomes increasingly difficult to create the many "guiding channels" that act like wires to move electrons around the circuit components.
Researchers in Leicester, England and Michigan will begin tests on a new cancer prevention drug, based on a natural compound found in red wine. The compound, resveratrol, is a natural agent found in grapes, peanuts and several berries. It is present in fruit juice from these berries and in wine. Consumption of resveratrol has been proposed as one possible explanation for the low incidence of cardiovascular disease in Southern European countries with high red wine consumption, and resveratrol has been shown to possess anti-inflammatory and anti-cancer activity in experimental models.
Michigan researchers have found an elusive microbe whose pickiness could be key to the cleanup of a common type of environmental toxin. The researchers report the discovery of a microbe dredged from the bottom of the Hudson River that has an insatiable appetite to break down the environmental pollutant TCA. That means the bacterium shows promise as the missing piece of the puzzle to clean up soil and groundwater contaminated by multiple chlorinated solvents.
