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Study shows long-term use of NSAIDs causes severe intestinal damage

January 3, 2005

According to a study published today in the American Gastroenterological Association (AGA) journal Clinical Gastroenterology and Hepatology, chronic users of non-steroidal anti-inflammatory drugs (NSAIDs) have an increased risk of bleeding and visible damage to their small intestine. "We have always known that NSAIDs can cause potentially deadly stomach complications, but the extent of the impact on the small intestine was largely unknown until now," said David Graham, MD, lead study author. "The introduction of video capsule endoscopy gave us an opportunity to examine the small intestine and learn that NSAIDs can cause severe damage to this organ."

FDA tried to discredit whistleblower over drug safety claims

November 25, 2004

The Food and Drug Administration tried to discredit one of its own experts after he told a US Senate hearing that the FDA had failed to protect the public over rofecoxib (Vioxx), according to two articles published online by the BMJ today. Dr David Graham, Associate Director in the FDA's Office of Drug Safety, said that the FDA was ''incapable of protecting America against another Vioxx.'' He also indicated that five other drugs currently on the market may be endangering patients.



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