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Metobolomics uncovers key indicators of nonalcoholic fatty liver disease

A recent metobolomics study by researchers from Virginia Commonwealth University Medical Center in Richmond found that impaired peroxisomal oxidation of polyunsaturated fatty acids (PUFA) is associated with the progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH).

Researchers identify role of gene in tumor development, growth and progression

RICHMOND, Va. (Nov. 20, 2009) -- Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.

Optimized inhaler mouthpiece design allows for more effective drug delivery

Researchers have developed an optimized mouthpiece design to aid efficient drug delivery to the lungs by reducing the amount of medication wasted as it passes through the mouthpiece of an aerosol inhaler. With current inhaler designs, only approximately 10 to 20 percent of asthma medications are delivered to the lungs.

Psychiatric disorders and sexual trauma are associated with lower urinary tract symptoms

New York, NY, October 20, 2009 -- Depression, anxiety disorders and sexual trauma have all been implicated as risk factors in lower urinary tract symptoms (LUTS) such as incontinence and overactive bladder. The exact nature of these associations is unknown.

Researchers identify gene with possible link to infertility in mice

RICHMOND, Va. (Oct. 2, 2009) -- Virginia Commonwealth University researchers have identified the role of a gene in regulating molecular signals involved with ovarian follicle development, which may one day help shed light on some of the causes of fertility issues in humans.

Survey: Men may not be adequately involved in decisions about prostate cancer screening

Men largely make decisions about prostate cancer screening based on conversations with their clinicians, but these discussions often do not include information about the risks of testing in addition to the benefits, according to a report in the September 28 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Patients with cirrhosis and impaired cognitive abilities have more motor vehicle accidents

A recent study by Jasmohan Bajaj, M.D., and colleagues from Virginia Commonwealth University and McGuire VA Medical Center found that patients with cirrhosis of the liver who developed minimal hepatic encephalopathy (MHE) had a 16% rate of motor vehicle crashes compared to only 4% of those without MHE over one year.

Researchers design new graphene-based, nano-material with magnetic properties

RICHMOND, Va. (Sept. 1, 2009) -- An international team of researchers has designed a new graphite-based, magnetic nano-material that acts as a semiconductor and could help material scientists create the next generation of electronic devices like microchips.

Researchers find high-dose therapy for liver disease not effective

ROCHESTER, Minn. -- A national team of researchers led by scientists at Mayo Clinic has found that a common treatment for primary sclerosing cholangitis, a chronic liver disease, is not helpful for patients, according to a study published this month in the journal Hepatology.

Current hepatitis C treatments work equally well, UT Southwestern and national researchers report

DALLAS -- Aug. 6, 2009 -- The three treatment combinations for clearing the most common form of the hepatitis C virus work equally well with similar side effects, UT Southwestern Medical Center researchers and their colleagues in 13 other institutions have found.

Twin study examines associations between depression and coronary artery disease

Major depression and coronary artery disease are only modestly related throughout an individual's lifetime, but studying how the two interact over time and in twin pairs paints a more complex picture of the associations between the conditions, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Researchers identify new method to selectively kill metastatic melanoma cells

RICHMOND, Va. (August 3, 2009) -- An international team of researchers has identified a new method for selectively killing metastatic melanoma cells, which may lead to new areas for drug development in melanoma -- a cancer that is highly resistant to current treatment strategies.

ORNL advances therapy for Parkinson's, other diseases

OAK RIDGE, Tenn., July 22, 2009 -- By miniaturizing a device that monitors the delivery of healthy cells, researchers at Department of Energy's Oak Ridge National Laboratory are developing a powerful instrument for physicians to use in treating patients with Parkinson's syndrome, brain tumors and other diseases.

Researchers identify genes linked to chemoresistance

RICHMOND, Va. (July 20, 2009) -- Two genes may contribute to chemotherapy resistance in drugs like 5-fluorouracil, which is used in liver cancer treatment, according to Virginia Commonwealth University Massey Cancer Center researchers.



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