University of California, San Diego
By making use of model compounds in drug design, chemists at the University of California, San Diego identified a class of molecules that could lead to treatments for a wide range of diseases, including cancer, arthritis, and heart disease.
Enzymes--protein catalysts--in the body that help break down connective tissue like collagen are important in growth and wound healing, but also play a role in many diseases. For example, these enzymes are overactive in arthritis and are used by cancer cells to migrate through connective tissue and spread. While a number of drugs have been designed to inhibit these enzymes, only one has made it through clinical trials because of a variety of drawbacks.
Medical schools received 45 percent of all federal research and development funds provided to U.S. colleges and universities in the 2002 fiscal year, according to a RAND Corporation study that gives the most complete profile ever of how such funds are distributed. The nation's 126 medical schools received $9.6 billion of the $21.4 billion in federal research and development funds awarded in FY 2002 to the nearly 800 separate campuses of U.S. colleges and universities that received some federal research and development funding. There are more than 1,825 separate campuses of four-year accredited and professional degree-granting colleges and universities in the United States.
A team of California scientists made headlines four years ago when it reported finding one of the largest insect colonies in the world - a 600-mile-long subterranean network of Argentine ants stretching from Northern California to the Mexican border. According to the researchers, this ''supercolony'' is made up of billions of closely related workers - all direct descendants of a small group of Argentine ants that were accidentally introduced into California more than a century ago. But new studies by Stanford University scientists are raising serious doubts about the existence of a single supercolony running through the Golden State. The Stanford team questions the notion that Los Angeles ants are descended from the same founding population as San Francisco ants, which live 400 miles away.
A team of physicists has developed a class of materials that respond magnetically to terahertz radiation, a fundamental finding relevant to many exciting applications in areas including guidance in zero visibility weather conditions, security and biomedical imaging and quality control. The materials are metamaterials -- artificially structured materials that extend the properties of existing naturally occurring materials and compounds.
DNA from inactivated "probiotic" bacteria triggers a specific anti-inflammation immune response in mice with experimental colitis, researchers supported by the NIH's National Institute of Allergy and Infectious Diseases (NIAID) have discovered. The investigators provide a possible explanation for the observed benefits of consuming probiotics, supplements from bacteria and other microbes, regarded by some as helpful in maintaining or restoring intestinal health. Knowing how probiotics work could give scientists a way to identify and select which probiotic bacteria might be effective against such human ailments as inflammatory bowel disease.
A non-human, cellular molecule is absorbed into human tissues as a result of eating red meat and milk products, according to a study by researchers at the University of California, San Diego (UCSD) School of Medicine, published online the week of September 29, 2003 in Proceedings of the National Academy of Sciences. The researchers also showed that the same foreign molecule generates an immune response that could potentially lead to inflammation in human tissues.
Biologists at the University of California, San Diego have determined that a protein essential for the normal embryonic development of fruit flies is also used by mammals to assist in the timely healing of cuts and lacerations. Their discovery, detailed in the June 3 issue of the journal Developmental Cell, provides new insight for scientists into the molecular mechanisms responsible for wound healing in humans and may one day lead to the design of new drugs for individuals whose healing is compromised.
Men are from Mars and women are from Venus, or so we've been told, and when it comes to jealousy this is especially true. Men, psychologists have long contended, tend to care more about sexual infidelity while women usually react more strongly to emotional infidelity. This view has long been espoused by evolutionary psychologists who attribute these gender differences to natural selection, which, they say, encouraged the sexes to develop different emotional reactions to jealousy. However, a recent research paper published in Personality and Social Psychology Review by Christine Harris, a psychologist with the Center for Brain and Cognition at the University of California, San Diego, casts serious doubts on this view of gender differences on jealousy and argues that more men and women appear to view sexual and emotional jealousy in the same light.
The method that Staphylococcus aureus (staph) infection uses to inactivate the body's immune response and cause previously healthy B cells to commit suicide, is described for the first time by researchers at the University of California, San Diego (UCSD) School of Medicine. Normally, B cells mount an early defense against invading bacteria. From this immunologic experience, memory B cells are developed with the ability to quickly recognize these antigens and destroy the bacteria if they return in the future. When staph infections occur, however, this important process for immune defense can be corrupted.
A team of researchers has developed a novel new brain imaging technique that produces maps that "light up" the relationship between the severity of a behavioral deficit and the voxels (similar to pixels in computer images) in the brain that contribute the most to that deficit. Discovery of the new technique, known as Voxel-based Lesion-Symptom Mapping (VLSM) will give researchers an invaluable new tool for pinpointing the specific areas of the brain that are most crucial for normal functioning during critical brain activities, starting with the measures of language comprehension and production that were used for the first demonstration in Nature Neuroscience, but moving on to many different language and non-language functions.
Scientists in California have provided the first detailed look at how human antibodies, proteins critical for the body's defense against invading pathogens, may actually drive human immunodeficiency virus (HIV) to mutate and escape detection by the immune system. The findings, reported online March 18 in the Proceedings of the National Academy of Sciences, may be key in efforts to develop an effective AIDS vaccine.
Two versions of an oral drug that halts the deadly action of smallpox and related orthopox viruses have been shown by researchers in Alabama and California to be effective in cowpox-infected mice, whether given three to five days before or two to three days after infection. The study evaluated the dosage regimen and effectiveness of four different ether lipid analogs of cidofovir (CDV), a compound that blocks the activity of variola, the virus that causes smallpox, cowpox, vaccinia and other orthopox viruses. Shown most effective in treating lethal cowpox infection in mice were hexadecyloxypropyl-CDV (HDP-CDV) and octadecyloxyethyl-CDV (ODE-CDV). In addition, the study pinpointed the time period for effectiveness when the drug is administered prior to or after infection.
Biologists at the University of California, San Diego have discovered that Bacillus thuringiensis, or Bt -- a bacterium that produces natural protein insecticides that have been used by organic farmers for five decades -- can also produce similar natural proteins that kill nematodes. The discovery could pave the way for the development of an inexpensive and environmentally safe means of controlling the parasitic roundworms that each year destroy billions of dollars in crops, cause debilitating diseases in farm animals and pets, and now infect a quarter of the world's human population.
America is facing a major roadblock to medical progress. For the speedy translation of promising scientific discoveries into patient treatment, we need a special breed of medical researchers who are trained to ask clinically relevant questions in a health research environment. It's these individuals who transform clinical observations into research studies and eventual medical advances.
Researchers have identified an over-active gene and the molecular events it triggers to cause acquired cases of pulmonary hypertension, a form of high blood pressure in the lungs that kills about one percent of the population each year. The findings, published in the February 6, 2003 issue of the New England Journal of Medicine, offer the first specific molecular targets for development of new therapies.
