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Brain irradiation in lung cancer

A national Radiation Therapy Oncology Group (RTOG) study led by a Medical College of Wisconsin Cancer Center physician at Froedtert Hospital in Milwaukee has found that a course of radiation therapy to the brain after treatment for locally advanced non-small cell lung cancer reduced the risk of metastases to the brain within the first year after treatment.

Tear research focused on contact lens risks, benefit

BIRMINGHAM, Ala. - Contact lenses are great for sight, but do they have an impact on general eye health? Researchers at the University of Alabama at Birmingham (UAB) School of Optometry are working to answer that question by analyzing tears.

UAB study finds social support key

BIRMINGHAM, Ala. - It is not uncommon for prison inmates to experience religious conversions. Now a new University of Alabama at Birmingham (UAB) study, out in the April issue of the International Journal of Offender Therapy and Comparative Criminology, suggests that inmates who have positive social support networks are more likely to maintain their religious conversions.

Certain ecologic factors associated with greater risk of bladder cancer

LINTHICUM, MD, April 26, 2009-Persons drinking well water (as opposed to public supply) may be at an increased risk of bladder cancer, according to new research from the University of Alabama at Birmingham.

VA/UAB study looks at functional decline in older patients after hospitalization

BIRMINGHAM, Ala. - Motivation and expectation may be factors in helping older adults regain lost functional ability after hospitalization, say researchers with the Birmingham Veterans Administration Medical Center and UAB (University of Alabama at Birmingham).

Ovarian cancer screening not catching early disease

BIRMINGHAM, Ala. - The only available screening tests for ovarian cancer fail to catch early signs of the disease and often result in unnecessary surgery, said researchers at the University of Alabama at Birmingham (UAB) Comprehensive Cancer Center.

The new study looked at a screening regimen that combines ultrasound and a blood test for CA-125, a marker for women's cancer.

Genetic link uncovered in disparate colon cancer death

BIRMINGHAM, Ala. - A new study reveals the first-ever genetic link to the reason African-Americans are at increased risk of dying from colon cancer.

Increase in P53 mutation linked to advanced colorectal cancer in blacks

PHILADELPHIA - Researchers have identified a possible genetic cause for increased risk for a more advanced form of colorectal cancer in blacks that leads to shorter survival, according to data published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

HIV adapts to 'escape' immune response

The human immunodeficiency virus (HIV) adapts so well to the body's defense system that any successful AIDS vaccine must keep pace with the ever-changing immunological profile of the virus, according to researchers at the University of Alabama at Birmingham (UAB) and the University of Oxford in England.

Women less likely to have a stroke after mini-stroke

That first "mini-stroke" may be more of a benign event for women than men, according to researchers at the University of Alabama at Birmingham (UAB) and Yale University. The findings underscore the need to continue researching gender differences in disease prevention and follow-up care.

UAB researchers report breakthrough in HPV research

UAB (University of Alabama at Birmingham) researchers have developed a new, inexpensive and efficient method for producing and studying a type of human papillomavirus (HPV) that causes cervical cancer. The process could speed understanding of how the virus functions and causes diseases, and lead to new prevention or treatment options.

Treatment yields new hope for children with cerebral palsy

Children with cerebral palsy who are severely impaired showed significant improvement in their motor skills using a new experimental physical therapy regimen, said researchers. The study ? the first randomized, controlled trial of its kind conducted on children ? appears in the February 2 issue of the journal Pediatrics. All treated children in this study outperformed the children in conventional therapy across all measures of success, including how well they could move their arms post-therapy and their ability to do new tasks during research and at home with their families.

Smart Virus Eliminates Brain Cancer In Animal Experiments

A research team led by The University of Texas M. D. Anderson Cancer Center has tested a novel "viral smart bomb" therapy that can completely eradicate brain tumors in mice, while leaving normal brain tissue alone. The therapy, known as Delta-24-RGD, is thought to be the first treatment for malignant glioma, the deadliest form of brain cancer. It is a new-generation "replication-competent oncolytic" adenovirus therapy ?? defined as a therapeutic virus that can spread, wavelike, throughout a tumor, infecting and killing cancer cells. There is no adequate treatment for these deadly brain cancers and, before this study, few experimental therapies tested in animals have shown much improvement.

Components of diabetes in African Americans have genetic underpinnings

American children whose genetic roots strongly reach back to Africa are less sensitive to insulin-a factor important in the development of type 2 diabetes-than those whose ancestors hailed heavily from Europe, according to study results released today. Rather than relying on broad categories of race, such as black or white, researchers in diabetes and obesity from the Keck School of Medicine of USC and the University of Alabama at Birmingham analyzed a group of children for 20 key genetic markers found far more often in those of African descent than those of European descent. They found that the more African-origin markers in children's genetic makeup, the less their bodies responded to insulin-and the more insulin in their blood.

Deceptive Strategy Shields HIV from Destruction

Researchers have discovered one way in which the human immunodeficiency virus (HIV) wins its cat-and-mouse game with the body's immune system. The study, published in the March 20, 2003, issue of the journal Nature, shows that HIV-1, a common strain of the virus that causes AIDS, uses a strategy not seen before in other viruses to escape attack by antibodies, one of the immune system's prime weapons against invading viruses and bacteria.



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