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Mathematical models reveal 'molten' and 'glassy' states of RNA

Mathematical models have given physicists a new look at DNA's chemical counterpart, RNA. The models -- showing that RNA behaves differently depending on the temperature of its environment -- may help biologists better understand how life evolved on Earth.

Rivers of gas could provide part of universe's 'missing matter'

An Ohio astronomer and her colleagues have detected a type of hot gas in space that could account for part of the "missing" matter in the universe. A gas cloud, one trillion times more massive than our sun and more than 150 times hotter, surrounds our local group of galaxies, the astronomers reported in the journal Nature. Though vast, this gas cloud is only part of larger rivers of gas that wind between all the galaxies of the universe.

Patients benefit when doctors use computers, not paper

Hospitals may be able to significantly cut the time it takes to deliver medications to patients and complete X-rays and lab tests by having doctors fill out orders via computer rather than by hand, a new study suggests. Results showed that computerized ordering also eliminated prescription drug errors that occurred when doctors' handwritten prescriptions were misread. The study found that computerizing physician orders cut medication turn-around times by 64 percent, cut turn-around times for X-rays and other radiology procedures by 43 percent, and reduced turn-around times for lab tests by 25 percent.

Chronic self-doubters likely to face wide range of problems

People who chronically doubt their judgments lead psychologically impoverished lives in a variety of ways, a new study suggests.
Such individuals often feel anxious, are prone to sadness and mood swings, and are likely to procrastinate and avoid thinking about difficult problems. "People who are dubious about their judgment are highly vulnerable," said Herbert Mirels, primary author of the study and professor of psychology at Ohio State University. "They see every important decision they make as a trial in which they are likely to find themselves deficient or to be found deficient by others."

Topical oxygen helps hard-to-heel wounds heal faster and better

A new study suggests that brief exposures to pure oxygen not only help chronic and other hard-to-heal wounds heal completely, such exposures also help wounds heal faster. Ohio State University surgical scientists used topical oxygen therapy to treat 30 patients with a total of 56 wounds. The therapy required placing a bag containing pure oxygen over the wound for 90 minutes a day. More than two-thirds of the difficult wounds healed with the oxygen treatment alone.

Too much oxygen on the cell biology bench? New study suggests so

Research conducted at Ohio State University suggests that cell biologists may be exposing the cell cultures they study to too much oxygen. This finding could have broad implications for cellular biology research, which receives billions of dollars of funding nationally, said Ohio State scientist Chandan Sen. He is the lead author of a study which suggests that cells act differently depending on how much oxygen they are exposed to, especially when it is too much.

'Moss in space' project to test how plants grow 'up'

An experiment scheduled for todays Space Shuttle Columbia mission may provide clues about just how plant growth is guided by gravity. The study, an extension of work from a previous shuttle mission in 1997, should test whether the absence of gravity changes how simple plants grow. The experiment will use common roof moss (Ceratodon purpureus), a plant that uses gravity to determine the direction that single cells grow.

Black holes form first, galaxies follow

A new study has uncovered more evidence that black holes form before the galaxies that contain them. The finding could help resolve a long-standing debate, says the study's lead scientist. Marianne Vestergaard, a postdoctoral fellow in astronomy at Ohio State, came to this conclusion when she studied a collection of very energetic, active galaxies known as quasars as they appeared some 12 billion years ago, when the universe was only one billion years old. While the quasars were obviously young -- they contained large stellar nurseries in which new stars were forming -- each also contained a very massive, fully formed black hole.

Gene mutations in breast tissue may make cancer detection more difficult

Until now, researchers thought that breast cancer nearly always began when cells in the epithelium went haywire. But new research suggests that genetic mutations can ? and do ? occur initially in a deeper layer of breast tissue, called the stroma. This presents a serious concern for physicians, who believed that breast tumors spread from epithelial tissue. "Genetic alterations in carcinomas, including breast cancers, have always been attributed to epithelial cells," said Charis Eng, Klotz professor and director of the Clinical Cancer Genetics Program at Ohio State University. She co-authored a new study that looks at genetic mutations in breast tissue.

Gelatin particles show promise in gene therapy for kidney disease

Researchers have successfully tested micro-sized gelatin particles that may one day deliver therapeutic genes to treat a type of kidney disease. The biodegradable gelatin particles are so small that at least 10 would fit on the period at the end of this sentence. Researchers believe such particles could carry therapeutic genes to the glomerulus, a tiny cluster of capillaries within the kidney that filters toxins from the blood. This filtration system becomes blocked when patients develop glomerular disease.

Grape seed extract may help wound healing

Grape-seed extract may help skin wounds heal faster and with less scarring, a new study suggests. The extract seemed to aid wound healing in two ways: It helped the body make more of a compound used to regenerate damaged blood vessels, and it also increased the amount of free radicals in the wound site. Free radicals help clear potentially pathogenic bacteria from a wound.

Listening to music while working out helps people with severe lung disease

Researchers believe that listening to music helped people with severe respiratory disease increase their fitness levels, based on the results of a new study. Subjects with serious lung disease who listened to music while walking covered an average of 19 total miles over the course of an eight-week exercise intervention study. In comparison, the group that didn't listen to music only walked an average of 15 total miles ? 21 percent less - by the end of the study. That four-mile difference is significant, said Gerene Bauldoff, a study co-author and an assistant professor of nursing at Ohio State University. It suggests that participants in the music group may have felt less hindered by shortness of breath, the primary physical symptom of serious lung disease.

Telescope mirror to get shiny finish in major test run

In an airplane hangar in Columbus, OH, some 80 tons of steel, electronics, and cryogenic equipment are about to come together -- all to deposit one ounce of aluminum as a near-perfect, whisper-thin coating on a giant telescope mirror. The successful operation of the coating system will represent a milestone in the construction of the Large Binocular Telescope (LBT), and a critical phase in Ohio State University 's participation in the LBT project.

Researchers link teen sex to early friendships

The nature of preteen friendships can play a key role in determining whether or not a child will engage in sexual activity early in adolescence, a new study suggests. For example, researchers found that boys who had mostly female friends when they were preteens were more likely to have had sex by age 16 than were other boys. However, the same wasn't true for girls who as preteens had mostly male friends.

Health of Native Americans on decline before Columbus' arrival

The health of indigenous people in the Western Hemisphere was on a downward trajectory long before Columbus set foot in the Americas, Ohio researchers say. The rise of agriculture is partly to blame as the demands of tending domestic crops encouraged people to settle in larger communities, where disease was more easily spread. The current research suggests that the overall health of the average person declined with the development of agriculture, government and urbanization.



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