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Gerton Lab determines the composition of centromeric chromatin

The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis. The work, conducted in yeast cells, was published in the most recent issue of Molecular Cell.

Swiss study finds income affects prostate cancer patients' survival

Prostate cancer patients of low socioeconomic status are more likely to die than patients with higher incomes. That is the finding of a new study from Swiss researchers to be published in the December 1, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society.

UCI researchers create new strategy for highly-selective chemotherapy delivery

Irvine, Calif. -- UC Irvine researchers have created a new approach that vastly improves the targeting of chemotherapeutic drugs to specific cells and organs.

M. D. Anderson examines use of toad venom in cancer treatment

HOUSTON - Huachansu, a Chinese medicine that comes from the dried venom secreted by the skin glands of toads, has tolerable toxicity levels, even at doses eight times those normally administered, and may slow disease progression in some cancer patients, say researchers from The University of Texas M. D. Anderson Cancer Center.

Novel 'on-off switch' mechanism stops cancer in its tracks

A tiny bit of genetic material with no previously known function may hold the key to stopping the spread of cancer, researchers at Yale School of Medicine and Sichuan University in Chengdu, China report in two papers in the September 7-11 issue of Proceedings of the National Academy of Sciences.

Study looks at using the immune system to reduce prostate cancer risk

ANN ARBOR, Mich. -- Immune therapies have been explored as a way to treat cancer after it develops. But a new study from the University of Michigan Comprehensive Cancer Center suggests that genetic risk of prostate cancer can be reduced by rescuing critical immune system cells.

Ultrasound can predict tumor burden and survival in melanoma patients

Berlin, Germany: Researchers have shown for the first time that patterns of ultrasound signals can be used to identify whether or not cancer has started to spread in melanoma patients, and to what extent. The discovery enables doctors to decide on how much surgery, if any, is required and to predict the patient's probable survival.

Therapeutic nanoparticles give new meaning to sugar-coating medicine

A research team at the National Institute of Standards and Technology (NIST) studying sugar-coated nanoparticles for use as a possible cancer therapy has uncovered a delicate balancing act that makes the particles more effective than conventional thinking says they should be.

Obesity hinders chemotherapy treatment in children with leukemia

PHILADELPHIA -- Obesity is an important factor contributing to chemotherapy resistance and increasing relapse rates among children with leukemia, according to recent findings published online first in Cancer Research, a journal of the American Association for Cancer Research.

Pancreatic fat levels may help predict diabetes, UT Southwestern researchers say

DALLAS -- Sept. 17, 2009 -- Researchers have long suspected that overweight people tend to have large fat deposits in their pancreases, but they've been unable to confirm or calculate how much fat resides there because of the organ's location.

Until now.

Study: Speaking, eating possible after tonsil cancer surgery with reconstruction

ANN ARBOR, Mich. -- A new technique for reconstructing the palate after surgery for tonsil cancer maintained patients' ability to speak clearly and eat most foods, a new study shows.

The technique, developed at the University of Michigan Comprehensive Cancer Center, is described in the September Archives of Otolaryngology -- Head & Neck Surgery.

Incomplete radiation therapy common among medicare recipients with head and neck cancer

Medicare recipients with head and neck cancer commonly do not complete radiation therapy without interruptions or at all, according to a report in the September issue of Archives of Otolaryngology?Head & Neck Surgery, one of the JAMA/Archives journals.

Role of Cancer Stem Cells in the Development of the Tumor Vasculature

September 21, 2009 by jenwjw

A common strategy to stop tumor growth is to cut the tumor's blood supply, usually by inhibiting angiogenic factors such as the vascular endothelial growth factor (VEGF). However, recent evidence suggests that anti-angiogenic therapy could also enhance tumor growth and invasiveness in the long-term [1].

Short-term stress enhances anti-tumor activity in mice, Stanford study shows

STANFORD, Calif. - Public speaking, anyone? Or maybe a big job interview? Dry your palms and take a deep, calming breath; there may be a silver lining. Researchers at the Stanford University School of Medicine have shown that, at least in laboratory mice, bouts of relatively short-term stress can boost the immune system and protect against one type of cancer.

Echoes of phlogiston in stem cell biology

Before it was learned that matter burns by taking up oxygen, most chemists sought to explain combustion as the release of a mysterious substance, which they named "phlogiston". Phlogiston theory was a conceptual breakthrough that helped chemists conduct experiments and share ideas.



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