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Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report

DALLAS -- July 30, 2009 -- The typical dose of a medication considered pivotal in treating tuberculosis effectively is much too low to account for modern-day physiques, UT Southwestern Medical Center researchers said.

Discovery to aid in future treatments of third-world parasites

Saranac Lake, NY - Schistosomiasis, one of the most important of the neglected tropical diseases, is caused by infection with parasitic helminths of the genus Schistosoma. These parasites are long lived (>10 years) and dwell within blood vessels, where they produce eggs that become the focus of intense, chronic inflammatory responses.

Leading health organizations launch new accreditation process for laboratories across Africa

KIGALI, Rwanda (July 27, 2009) -- Government health officials from 13 African countries today launched the first-ever push for accreditation of the continent's medical laboratories, starting a process that the World Health Organization (WHO) and the U.S. Government believe will be an historic step to strengthen health systems and lead to better care for patients.

Resistance to antibiotics: When 1+1 is not 2

The evolution of multiple antibiotic resistances is a global and difficult problem to eradicate.

Hopkins-designed animal TB 'tracker' to speed drug and vaccine studies

Johns Hopkins researchers have developed a novel way to monitor in real time the behavior of the TB bacterium in mouse lungs noninvasively pinpointing the exact location of Mycobacterium tuberculosis. The new monitoring system is expected to speed up what is currently a slow and cumbersome process to test the safety and efficacy of various TB drug regimens and vaccines in animals.

Researchers turn cell phones into fluorescent microscopes

Berkeley - Researchers at the University of California, Berkeley, are proving that a camera phone can capture far more than photos of people or pets at play. They have now developed a cell phone microscope, or CellScope, that not only takes color images of malaria parasites, but of tuberculosis bacteria labeled with fluorescent markers.

Earlier HIV antiviral treatment can be cost effective in areas of limited resources

Early initiation of lifesaving antiretroviral therapies should be the standard of care for all HIV-infected patients, even those in countries with limited medical and financial resources, according to a study led by researchers at Massachusetts General Hospital (MGH) and the Desmond Tutu HIV Centre, University of Cape Town, South Africa.

One secret to how TB sticks with you

Mycobacterium tuberculosis is arguably the world's most successful infectious agent because it knows how to avoid elimination by slowing its own growth to a crawl. Now, a report in the July 10 issue of the journal Cell, a Cell Press publication, offers new insight into the bugs' talent for meager living.

Measurements fail to identify TB patients who could benefit from shorter treatment course

Tuberculosis (TB) is a difficult infection to treat and requires six months of multiple antibiotics to cure it. To combat the TB pandemic, a shorter and simpler drug treatment would be a huge advance since most TB occurs in resource-limited settings with poor public health infrastructures.

Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection

A team of Harvard scientists has taken an important first step toward the development of new treatments to help people with HIV battle Mycobacterium tuberculosis (TB) infection.

Global health funding soars, boosted by unprecedented private giving

Well-heeled donors, private corporations and average citizens sending money to their favorite charities are changing the landscape of global health funding, according to a new study by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington.

IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases

INDIANAPOLIS ?Researchers from Indiana University-Purdue University Indianapolis (IUPUI) have developed Distributed Drug Discovery (D3), a new low-cost strategy to accelerate the discovery of drugs to treat neglected diseases such as tuberculosis, leprosy, leshmaniasis, dengue fever, and Chagas disease.

Unexpected discovery can open a new chapter in the fight against tuberculosis

A close relative of the microorganism that causes tuberculosis in humans has been found to form spores. This is a sensational finding because researchers have long been convinced that these kinds of bacteria?the mycobacteria?were incapable of forming spores.

Data on investigational drug TMC207 for MDR-TB published in New England Journal of Medicine

[Mechelen Belgium, June 3, 2009] ?Interim results from an ongoing phase 2, randomized, placebo-controlled trial of the investigational drug TMC207 for the treatment of multidrug-resistant tuberculosis (MDR-TB) were published in the New England Journal of Medicine today. TMC207 is being developed by Tibotec BVBA.

Big boost for global health called for in IOM report

WASHINGTON -- To fulfill America's humanitarian obligations as a member of the international community and to invest in the nation's long-term health, economic interests, and national security, the United States should reaffirm and increase its commitment to improving the health of developing nations, says a new report from the Institute of Medicine.



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