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Weighing costs, benefits of HIV treatments

HANOVER, NH -- Prevention versus treatment? Cost versus efficacy? So go two of the dilemmas looming over Dartmouth's Paul E. Palumbo, M.D., and his fellow researchers in the race to fight HIV and other infectious diseases in the developing world -- especially among women and their young children.

Tuberculosis patients can reduce transmissability by inhaling interferon through a nebulizer

New York, NY (September 14, 2009): A new study published in the September 15, 2009, issue of PLoS ONE found that patients with cavitary pulmonary tuberculosis receiving anti-TB medications supplemented with nebulized interferon-gamma have fewer bacilli in the lungs and less inflammation, thereby reducing the transmissibility of tuberculosis in the early phase of treatment.

Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study

While daily bathroom showers provide invigorating relief and a good cleansing for millions of Americans, they also can deliver a face full of potentially pathogenic bacteria, according to a surprising new University of Colorado at Boulder study.

UAB researchers find TB-prevention therapy is cost-effective option

BIRMINGHAM, Ala. -- University of Alabama at Birmingham (UAB) researchers have found that the cost of preventive antibiotic tuberculosis (TB) therapy for patients infected by human immunodeficiency virus (HIV) is generally less expensive than the reported cost of treating newly confirmed TB cases.

How to improve vaccines to trigger T cell as well as antibody response

Killed or disabled viruses have proven safe and effective for vaccinating billions worldwide against smallpox, polio, measles, influenza and many other diseases.

But killed or severely "attenuated" vaccines, which are safer than "live" vaccines, have been largely unsuccessful for many non-viral diseases, including illnesses like tuberculosis and malaria.

The path to new antibiotics

LA JOLLA, Calif., August 27, 2009 -- Researchers at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have demonstrated that an enzyme that is essential to many bacteria can be targeted to kill dangerous pathogens.

New analysis details devastating toll of neglected tropical diseases in sub-Saharan Africa

An analysis published August 25 in the open-access journal PLoS Neglected Tropical Diseases sheds new light on the toll that neglected tropical diseases (NTDs) take on sub-Saharan Africa (SSA), with an estimated 500 million people suffering from these debilitating and sometimes deadly diseases. Helminth infections account for approximately 85% of the NTD burden.

Smoking increases risk of developing active TB

Smoking is a risk factor for active tuberculosis (TB) disease, according to a new study on TB incidence in Taiwan.

The research analyzed data from nearly 17,000 individuals in Taiwan as part of Taiwan's 2001 National Health Interview Survey (NHIS).

Scientific community urges officials and public to use latest evidence as guide in H1N1 prevention and protection procedures

WASHINGTON, DC (August 11, 2009) - As flu season draws nearer along with the potential for resurgence in H1N1, leading infectious diseases doctors, hospital epidemiologists, and infection preventionists urge officials to base recommendations for the public and healthcare workers on scientific knowledge and frontline experience gained from the outbreak this summer.

Discovery could help stem infections of parasitic roundworms

Working with researchers in China, biologists at UC San Diego have discovered how a Chinese drug effective in killing parasitic roundworms works.

New drug-resistant TB strains could become widespread says new study

The emergence of new forms of tuberculosis could swell the proportion of drug-resistant cases globally, a new study has found. The finding raises concern that although TB incidence is falling in many regions, the emergence of antibiotic resistance could see virtually untreatable strains of the disease become widespread.

Misuse of common antibiotic is creating resistant TB

Use of a common antibiotic may be undercutting its utility as a first-line defense against drug-resistant tuberculosis (TB). Fluoroquinolones are the most commonly prescribed class of antibiotics in the U.S. and are used to fight a number of different infections such as sinusitis and pneumonia. They are also an effective first line of defense against TB infections that show drug resistance.

Tuberculosis drugs under development expected to have major impact on the disease

SEATTLE -- The latest drug regimens, vaccines and diagnostic tools under development to combat tuberculosis could have a potentially large impact on the disease once they become available, according to research findings published in the Aug. 3 early edition online of the Proceedings of the National Academy of Sciences.

Cannibalistic cells may help prevent infections, UT Southwestern researchers report

DALLAS -- Aug. 3, 2009 -- Infectious-disease specialists at UT Southwestern Medical Center have demonstrated that a cannibalistic process in cells plays a key role in limiting Salmonella infection.

Bacteria pack their own demise

Brussels - Numerous pathogens contain an 'internal time bomb', a deadly mechanism that can be used against them. After years of work, VIB researchers at the Vrije Universiteit Brussel (VUB) were able to determine the structure and operating mechanism of the proteins involved.



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