skin cancer
PROVIDENCE, R.I. [Brown University] -- Actinic keratoses are sun-damaged rough patches or lesions on the skin -- often pink and scaly -- that doctors have long believed can turn into a form of skin cancer known as squamous cell carcinoma.
You know the guy -- he's your Facebook friend. The one who knows everyone. Secure at the center of a dense web of relationships, he suggests causes and reconnects old friends like a skilled matchmaker. Scientists have known for some time that biological molecules interact with one another in a similarly complex pattern.
In a new study published in Disease Models & Mechanisms, scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options.
CINCINNATI--After comparing two patient cancer registries--one featuring transplant patients and the other the general population--researchers at the University of Cincinnati (UC) have found that transplant patients experience worse outcomes from cancer.
These results will be published in the May 15, 2009, edition of the journal Transplantation, which is currently in press.
National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cancer and many other types of cancer.
The year is 2065. Nearly two-thirds of Earth's ozone is gone -- not just over the poles, but everywhere. The infamous ozone hole over Antarctica, first discovered in the 1980s, is a year-round fixture, with a twin over the North Pole. The ultraviolet (UV) radiation falling on mid-latitude cities like Washington, D.C., is strong enough to cause sunburn in just five minutes.
Researchers have developed a new mouse model that allows them to replicate normal pigment cells at the earliest stages of conversion to malignant skin cancer in humans. After testing the mouse with a combination of two drug therapies, the team found the treatment caused a statistically significant regression in cancer cell development.
Cell lifespan is limited by telomeres, DNA sequences that cap chromosomes and control the number of times a cell may be copied. A new study reported in Disease Models & Mechanisms (DMM), dmm.biologists.org, describes how telomere dysfunction in skin cells can lead to increased skin cancer risk and pigmentation.
For patients with a particularly aggressive form of skin cancer – malignant melanoma – stress, including that which comes from simply hearing that diagnosis, might amplify the progression of their disease.
University of South Florida chemist Bill Baker, who spends much of his time diving in the frigid waters of Antarctica retrieving tunicates, blob-like marine animals, has isolated a compound in tunicate biochemistry that may fight melanoma, a type of skin cancer rising at alarming rates. "Tunicates have proven to be an important source of bioactive natural products," said Baker, who experimented with the tunicate Synioicum adareanum, retrieved from the shallow waters around Anvers Island. "We isolated a natural product in the species and sent it to the National Cancer Institute for testing against 60 different cancer cell lines. NCI conclude the compounded inhibited melanoma, a form of skin cancer that is rising in prevalence."
In a finding that broadens our insight into the cause of certain kinds of UV-induced skin cancer, researchers at Erasmus University Medical Center (Rotterdam, The Netherlands) have employed an evolutionarily ancient enzyme-repair system to identify the principal type of DNA damage responsible for the onset of skin-tumor development. The researchers' findings also suggest that this enzyme system may be useful in developing preventative therapies against skin cancer.
Scientists have identified genes that promote the growth and recurrence of skin cancer. Dr. Andrzej Dlugosz and colleagues at the University of Michigan and the National Cancer Institute have examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma, the most common form of cancer, and have uncovered a subset of tumor cells that are resistant to inhibition of the Hh pathway. This new finding has important implications for the treatment of this widespread disease.
Few things about growing older are as inevitable and obvious as "going gray," yet scientists have been unable to explain the precise cause of this usually unwelcome transformation. In a report posted today on the Web site of the journal Science, researchers from Dana-Farber Cancer Institute and Children's Hospital Boston say they have found the cellular cause of graying hair while investigating the origins of malignant melanoma, the potentially deadly skin cancer.
Researchers have discovered that malignant melanoma, the potentially lethal skin cancer, can't grow without a steady supply of a protein that normal cells can do without. The findings suggest that drugs that cut off melanoma cells' supply of the protein, called CDK2, might curb the growth of the dangerous skin cancer in patients, and with relatively low toxicity. In theory, such a drug would leave normal cells unharmed and have many fewer side effects compared to standard chemotherapy.
Does stress speed up the onset of skin cancer? The answer, in mice anyway, appears to be ''yes.'' Scientists at the Johns Hopkins Kimmel Cancer Center say that chronic stress may speed up the process in those at high-risk for the disease. Their new study, published in the December issue of the Journal of the American Academy of Dermatology, shows that mice exposed to stressful conditions and cancer-causing UV light develop skin cancers in less than half the time it took for non-stressed mice to grow tumors.
