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Novel drug discovery tool could identify promising new therapies for Parkinson's disease

Researchers funded by the National Institutes of Health have turned simple baker's yeast into a virtual army of medicinal chemists capable of rapidly searching for drugs to treat Parkinson's disease.

Ouch! Abrupt Opioid Withdrawal Increases Pain Sensitivity

July 13, 2009 by prandd

The abrupt withdrawal of morphine-like analgesics – opioids – can increase sensitivity to pain. Experiments have now shown that this effect is caused by a memory-like process, the long-term potentiation of synaptic strength in the spinal cord. The study, which was supported by the Austrian Science Fund FWF, also found ways of avoiding this increase in pain sensitivity.

Easy strength training exercise may help treat tennis elbow, study shows

KEYSTONE, CO -- People with pain in the elbow or forearm from playing sports or just from common everyday activities, might be able to use a simple bar and strengthening exercise to alleviate pain, say researchers who are presenting their study results at the American Orthopaedic Society for Sports Medicine's Annual Meeting in Keystone, Colorado, July 9th-12th.

A comprehensive review of addiction to prescription painkillers among patients and physicians

Chemical dependency and recovery in patients and physicians are closely examined in a series of articles and editorials in the July 2009 issue of Mayo Clinic Proceedings. The subject is especially timely. As the immense challenges, including potential tragedies, of prescription chemical addiction and abuse are being discussed, these articles offer crucial overview, direction and optimism.

New treatment for receding gums: No pain, lots of gain

BOSTON (July 1, 2009, 7 a.m. ET) -- Tufts dental researchers conducted a three-year follow-up study that examined the stability of a treatment option for receding gums and found that complete root coverage -- the goal of the surgery -- had been maintained.

Rotator cuff treatment provides immediate tendonitis relief

OAK BROOK, Ill. -- A minimally invasive procedure to treat tendonitis in the rotator cuff of the shoulder provides immediate symptom relief to the patient, according to a study published in the July issue of Radiology.

GIE: Gastrointestinal Endoscopy June issue study highlights

In the June issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE), a study looking at polyp detection rates at screening colonoscopy found a wide variation among endoscopists, though researchers note that further study is needed to determine the reasons for the variation and their clinical significance.

Diabetes is significant economic burden for US health-care system

New Rochelle, NY, June 25, 2009 -- Excess medical expenses and reduced productivity due to diabetes costs the U.S.

UAB researchers draft 3-D protein map to aid stroke, cancer research

BIRMINGHAM, Ala. -- A new three-dimensional computer protein map is helping researchers at the University of Alabama at Birmingham (UAB) unravel the biological pathways that control brain-cell death after a stroke.

Effective pain treatment for cancer patients?

Cancer patients often suffer from severe pain that cannot be effectively treated with conventional medication. Researchers at the Pharmacology Institute of the University of Heidelberg have found the possible reasons for this -- tumors release two signal substances that make nerve cells especially sensitive and enhance tumor growth.

Johns Hopkins scientists out a gene for gout

Having partnered last year with an international team that surveyed the genomes of 12,000 individuals to find a genetic cause for gout, Johns Hopkins scientists now have shown that the malfunctioning gene they helped uncover can lead to high concentrations of blood urate that forms crystals in joint tissue, causing inflammation and pain -- the hallmark of this disease.

Stanford expert lists 5 steps to boost impact of comparative effectiveness research

STANFORD, Calif. -- Comparative effectiveness research is generating buzz these days, with the recent economic stimulus package allocating $1.1 billion for these types of studies. But a researcher at the Stanford University School of Medicine is asking policymakers to take a step back and make sure that the plans for comparative effectiveness research go deep enough to make a difference.

Novel light-sensitive compounds show promise for cancer therapy

SANTA CRUZ, CA--Chemists at the University of California, Santa Cruz, have developed novel compounds that show promise for photodynamic cancer therapy, which uses light-activated drugs to kill tumor cells.

Knee replacements: Pinpointing the cause of infection

TORONTO -- A new study reveals that PET scans accurately detect infections in prosthetic knee joints more than 90 percent of the time, according to researchers at the SNM's 56th Annual Meeting. The findings could represent a significant breakthrough in the treatment of patients who undergo joint replacements. Joint replacements are prone to a number of complications following implantation.

Canakinumab shows promising efficacy and tolerability in children with systemic JIA

Copenhagen, Denmark, Saturday 13 June 2009: Canakinumab (ACZ885), a new interleukin-1 (IL-1)-beta blocking monoclonal antibody, shows encouraging efficacy and is well tolerated in children with systemic juvenile idiopathic arthritis (sJIA)*, according to a new phase II study presented today at PReS 2009, a joint congress with the 2009 Congress of the European League Against Rheumatism (EULAR) i



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