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Largest gene study of childhood IBD identifies 5 new genes

In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.

Thoughtful words help couples stay fighting fit

Couples who bring thoughtful words to a fight release lower amounts of stress-related proteins, suggesting that rational communication between partners can ease the impact of marital conflict on the immune system.

"Previous research has shown that couples who are hostile to each other show health impairments and are at greater risk of disease," said Jennifer Graham, assistant professor of

Anti-tumor necrosis factor treatment does not increase cancer Risk in RA patients

A recent study by Swedish researchers found that rheumatoid arthritis (RA) patients did not experience an elevated cancer risk in the first 6 years after starting anti-tumor necrosis factor (TNF

Ulcerative colitis treatment reduces need for surgery by almost half

ROCHESTER, Minn -- A new study led by Mayo Clinic researchers has found that ulcerative colitis patients had a 41 percent reduction in colectomy after a year when treated with infliximab, according to a study published in the October 2009 issue of Gastroenterology.

Polymorphisms of the interleukin-1 gene complex may influence alcohol dependence

Cytokines are small proteins secreted by cells that serve as molecular messengers between cells. Pro-inflammatory cytokines -- which function in the immune system -- may be involved in alcohol dependence (AD).

Insulin, metformin do not reduce inflammatory biomarkers for diabetes patients

CHICAGO -- In patients with recent onset type-2 diabetes, treatment with insulin or the diabetes drug metformin did not reduce inflammatory biomarkers, such as high-sensitivity C-reactive protein, although the treatment did improve glucose control, according to a study in the September 16 issue of JAMA.

Fewer injection site reactions in patients using Avonex

CAMBRIDGE, MA -- Sept. 11, 2009 -- Data from an observational phase IV study of 499 patients entitled The Swiss MS Skin Project show that multiple sclerosis (MS) patients taking AVONEX (interferon beta-1a IM) reported significantly fewer injection site reactions (ISRs) compared to patients on Betaferon® (interferon beta-1b), Copaxone® (glatiramer Acetate) or Rebif ® (interferon beta-1a).

Casting out devils

In the scientific journal PLoS ONE, Sara Bartels and Siegfried Weiss of the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany now show how the bacteria migrate into tumours. A messenger substance from the immune system is the door opener: It makes blood vessels in the cancerous tissue permeable; enabling the bacteria to conquer and destroy the tumour.

Infections may lead to faster memory loss in Alzheimer's disease

ST. PAUL, Minn. -- Getting a cold, stomach bug or other infection may lead to increased memory loss in people with Alzheimer's disease, according to research published in the September 8, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.

Watermelon's hidden killer

CHARLESTON, SC -- Watermelon vine decline (WVD) is a new and emerging disease that has created devastating economic losses for watermelon producers in Florida. Caused by the whitefly-transmitted squash vein yellowing virus (SqVYV), the disease created monetary losses estimated at $60 to $70 million in Florida during the 2004 growing season.

Smoking increases risk of developing active TB

Smoking is a risk factor for active tuberculosis (TB) disease, according to a new study on TB incidence in Taiwan.

The research analyzed data from nearly 17,000 individuals in Taiwan as part of Taiwan's 2001 National Health Interview Survey (NHIS).

News briefs from the July issue of CHEST

SMOKING CESSATION MAY PROVIDE IMMEDIATE BENEFIT TO HEART

Statins can protect against Alzheimer's disease, according to new study

Amsterdam, The Netherlands, June 22, 2009 -- High cholesterol levels are considered to be a risk factor not only for cardiovascular disease including stroke, but also for the development of Alzheimer's disease. Therefore, many cholesterol lowering drugs, including statins, have been developed in recent years.



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