mental retardation
The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St.
The loss of a gene through deletion of genetic material on chromosome 15 is associated with significant abnormalities in learning and behavior, said a consortium of researchers led by Baylor College o
NIH-supported scientists at Seaside Therapeutics in Cambridge, Mass., are beginning a clinical trial of a potential medication designed to correct a central neurochemical defect underlying Fragile
I had always though that refusal to get a flu vaccination was relatively harmless masochism. Refusal to vaccinate one's own children, on the other hand, should probably be prosecuted as child abuse, but at the least the negative consequences stay close to home.
Yale University researchers have found a molecular mechanism that allows the proper mixing of neurons during the formation of columns essential for the operation of the cerebral cortex, they report in the Sept. 16 online issue of the journal Nature.
ST. PAUL, Minn. -- A new guideline from the American Academy of Neurology, developed in full collaboration with the Child Neurology Society, finds that children with microcephaly that is, children whose head size is smaller than that of 97 percent of childrenare at risk of neurologic and cognitive problems and should be screened for these problems.
UCSF researchers have successfully used protease inhibitors to restore to normal levels a key protein involved in early brain development. Reduced levels of that protein have been shown to cause the rare brain disorder lissencephaly, which is characterized by brain malformations, seizures, severe mental retardation and very early death in human infants.
CHAPEL HILL -- In laying down the neural circuitry of the developing brain, billions of neurons must first migrate to their correct destinations and then form complex synaptic connections with their new neighbors.
A newly designed computational method has proven its usefulness in counting copies of duplicated genome sequences and in doing initial assessments of their contents, according to a study to be published Aug. 30 in Nature Genetics. The number of copies of particular DNA segments can differ from one person to the next.
PITTSBURGH -- With more than 1,500 eyes, not much escapes the fruit fly's sight. Now, a new research report in the journal GENETICS (http://www.genetics.org), describes how researchers from the United States and Ireland used those eyes to "see" new proteins necessary for memory.
LA JOLLA, CA -- August 17, 2009 Using advanced brain imaging and genomics technologies, an international team of researchers co-led by Scripps Research Institute scientists has shown for the first time that natural variations in a specific gene influence brain structure.
An international group of researchers is the first to show that common variations in a gene -- previously shown to be associated with Retts Syndrome, autism, and mental retardation -- are associated with differences in brain structure in both healthy individuals and patients with neurological and psychiatric disorders.
A genetic search that wound its way from patients to mouse models and back to patients has uncovered an unlikely gene critically involved in a common birth defect which causes mental retardation, motor delays and sometimes autism, providing a new mechanism and potentially improving treatment for the disorder.
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies. Their findings, which may lead to new therapies for these diseases, will appear in the online edition of Nature Genetics on August 9.
CINCINNATI -- Inhibiting an enzyme in the brains of newborns suffering from oxygen and blood flow deprivation stops a type of brain damage that is a leading cause of cerebral palsy, mental retardation and death, according to researchers at Cincinnati Children's Hospital Medical Center.
