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Whole-brain radiotherapy after surgery or radiosurgery not recommended for brain metastases

Berlin, Germany: Whole-brain radiotherapy should not be given routinely to all patients whose cancer has spread to the brain, say researchers who found that using it after surgery or radiosurgery in patients with a limited number of brain metastases and stable cancer in the rest of the body did not extend lives or help patients remain functionally independent for longer.

Nationwide study examines youth access to indoor tanning

Many indoor tanning businesses require parental consent for teenagers to use their facilities, but most would allow young tanners more than the government-recommended amount of exposure during the first week, according to a report in the September issue of Archives of Dermatology, one of the JAMA/Archives journals.

Tanning may be associated with moles in very light-skinned children

Very?light-skinned children without red hair who tan appear to develop more nevi (birthmarks, moles or other colored spots on the skin) than children who do not tan, according to a report in the September issue of Archives of Dermatology, one of the JAMA/Archives journals.

Reactive oxygen's role in metastasis

LA JOLLA, Calif., September 15, 2009 -- Researchers at the Burnham Institute for Medical Research (Burnham) have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumor metastasis.

Autoimmune response can induce pancreatic tumor rejection

PHILADELPHIA -- Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research.

Malignant signature may help identify patients likely to respond to therapy

A molecular signature that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a particular anti-cancer drug.

NIH study reveals new genetic culprit in deadly skin cancer

Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma.

Antioxidants not associated with increased melanoma risk

Antioxidant supplements do not appear to be associated with an increased risk of melanoma, according to a report in the August issue of Archives of Dermatology, one of the JAMA/Archives journals.

Dermatologist skin examinations detect more, thinner skin cancers than patients identify themselves

Most melanomas detected in a general-practice dermatology clinic were found by dermatologists during full-body skin examinations of patients who had come to the clinic for different complaints, according to a report in the August issue of Archives of Dermatology, one of the JAMA/Archives journals.

Budesonide is not beneficial for the treatment of diarrhea in metastatic melanoma patients

PHILADELPHIA -- Patients with stage III or IV melanoma taking ipilimumab and the oral steroid budesonide to reduce side effects did not have less diarrhea, a known side effect of ipilimumab, according to results of a phase II trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Tumors feel the deadly sting of nanobees

When bees sting, they pump poison into their victims. Now the toxin in bee venom has been harnessed to kill tumor cells by researchers at Washington University School of Medicine in St. Louis. The researchers attached the major component of bee venom to nano-sized spheres that they call nanobees.

Study identifies risk factors for transformation of eye growths into melanoma

Eight factors may predict whether a choroidal nevus -- a benign, flat, pigmented growth inside the eye and beneath the retina -- may develop into melanoma, according to a report in the August issue of Archives of Ophthalmology, one of the JAMA/Archives journals.

Wistar scientists find key to strengthening immune response to chronic infection

PHILADELPHIA -- (August 6, 2009) -- A team of researchers from The Wistar Institute has identified a protein that could serve as a target for reprogramming immune system cells exhausted by exposure to chronic viral infection into more effective "soldiers" against certain viruses like HIV, hepatitis C, and hepatitis B, as well as some cancers, such as melanoma.

Sensitizing tumor response to cancer therapy

Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.

Viral mimic induces melanoma cells to digest themselves

Recent research has uncovered an unexpected vulnerability in deadly melanoma cells that, when exploited, can cause the cancer cells to turn against themselves.



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