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H1N1 critical illness can occur rapidly; predominantly affects young patients

Critical illness among Canadian patients with 2009 influenza A(H1N1) occurred rapidly after hospital admission, often in young adults, and was associated with severely low levels of oxygen in the blood, multi-system organ failure, a need for prolonged mechanical ventilation, and frequent use of rescue therapies, according to a study to appear in the November 4 issue of JAMA.

Critical illness from 2009 H1N1 in Mexico associated with high fatality rate

Critical illness from 2009 influenza A(H1N1) in Mexico occurred among young patients, was associated with severe acute respiratory distress syndrome and shock, and had a fatality rate of about 40 percent, according to a study to appear in the November 4 issue of JAMA.

NIH launches 2009 H1N1 influenza vaccine trials in HIV-infected pregnant women

The first clinical trials to test whether the 2009 H1N1 influenza vaccine can safely elicit a protective immune response in pregnant women launched yesterday, and a trial to conduct the same test in HIV-infected children and youth will begin next week.

Lessons learned from H1N1 virus pandemic

A comprehensive study has revealed, for the first time, the impact of swine flu on the health of the general public in Australia and New Zealand.

The lessons learned in Intensive Care Units (ICUs) across the two countries on the impact of the H1N1 (swine flu) virus are being shared with countries in the Northern Hemisphere to help them prepare for their upcoming flu season.

Embargoed news from Annals of Internal Medicine

Early Releases:

1. Earlier H1N1 Vaccination Prevents More Deaths, Saves Health Care Costs

A vaccine for H1N1 influenza is anticipated to become available this fall. With the amount and timing of vaccine release still in question, policy makers struggle to set priorities regarding who should be vaccinated when.

High mortality rates may explain small body size

A new study suggests that high mortality rates in small-bodied people, commonly known as pygmies, may be part of the reason for their small stature. The study, by Jay Stock and Andrea Migliano, both of the University of Cambridge, helps unravel the mystery of how small-bodied people got that way.

The article appears in the October issue of Current Anthropology.

New aging studies improving vaccine efficacy for the elderly

Saranac Lake, NY -- A new study from the Trudeau Institute in Saranac Lake, New York, demonstrates that immune system cells important for both pathogen resistance and vaccine efficacy live longer in older animals but because of this longevity acquire functional defects. The work may provide new targets for boosting immune system function in older individuals.

Aspirin misuse may have made 1918 flu pandemic worse

The devastation of the 1918-1919 influenza pandemic is well known, but a new article suggests a surprising factor in the high death toll: the misuse of aspirin. Appearing in the November 1 issue of Clinical Infectious Diseases and available online now, the article sounds a cautionary note as present day concerns about the novel H1N1 virus run high.

Surgical masks and N95 respirators provide similar protection against influenza

Hamilton, ON (October 1, 2009) -- A McMaster University study has found that surgical masks appear to be as good as N95 respirators in protecting health-care workers against influenza.

Surgical masks vs. N95 respirators for preventing influenza among health-care workers

Surgical masks appear to be no worse than, and nearly as effective as N95 respirators in preventing influenza in health care workers, according to a study released early online today by JAMA. The study was posted online ahead of print because of its public health implications. It will be published in the November 4 issue of JAMA.

Protect children first with H1N1 flu vaccine, says UAB-based national pediatric disease expert

BIRMINGHAM, Ala. -- The optimal way to control swine flu, the new H1N1 virus that emerged as a global threat in 2009, is to vaccinate children with the planned H1N1 flu vaccine, says the co-director of the University of Alabama at Birmingham (UAB) Division of Pediatric Infectious Diseases.

Frozen assets: NIAID researchers turn to unique resource for clues to norovirus evolution

A search through decades-old frozen infant stool samples has yielded rich dividends for scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The team customized a laboratory technique to screen thousands of samples for norovirus, a major cause of acute gastroenteritis outbreaks in people of all ages.

Racing against the clock to distribute H1N1 flu vaccine

Drug companies are sprinting ahead in a race against the clock to deliver millions of doses of vaccine for the H1N1 influenza virus before cooler weather ushers in the 2009-2010 flu season. A two-part cover story in the current issue of Chemical & Engineering News, ACS' weekly newsmagazine, focuses on that topic and efforts to develop antiviral drugs for flu infections.

LSUHSC researcher identifies new target to prevent fatal flu lung complication

New Orleans, LA -- Research led by Dr. Jay Kolls, Professor and Chairman of Genetics at LSU Health Sciences Center New Orleans, has identified a therapeutic target for acute lung injury resulting in acute respiratory distress syndrome, a highly fatal complication of influenza infection.

U-M study: Life and death during the Great Depression

ANN ARBOR, Mich.---The Great Depression had a silver lining: During that hard time, U.S. life expectancy actually increased by 6.2 years, according to a University of Michigan study published in the current issue of the Proceedings of the National Academy of Sciences.



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