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Studies show dramatic decline in rheumatoid vasculitis in US veterans

Researchers at the University of Wisconsin School of Medicine and Public Health examined records of rheumatoid arthritis (RA) patients from the national Veterans Health Administration (VHA) system to determine the prevalence of rheumatoid vasculitis (RV) in this population.

Pitt study finds molecular link between insulin resistance and inflammation

PITTSBURGH, Aug. 26 -- An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC.

Resolvyx announces positive data -- Phase 2 trial of resolvin RX-10045 for dry eye syndrome

BEDFORD, MA ?August, 24, 2009 -- Resolvyx Pharmaceuticals, Inc., the leading resolvin therapeutics company, today announced positive data from a Phase 2 clinical study evaluating RX-10045, a resolvin administered as a topical eye drop for the treatment of patients with chronic dry eye syndrome.

How diarrheal bacteria cause some colon cancers revealed in mouse studies

Johns Hopkins scientists say they have figured out how bacteria that cause diarrhea may also be the culprit in some colon cancers. The investigators say that strains of the common Bacteroides fragilis (ETBF) dupe immune system cells into permitting runaway colon tissue inflammation, a precursor for malignant growth.

Research shows why low vitamin D raises heart disease risks in diabetics

Aug. 21, 2009 -- Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and researchers at Washington University School of Medicine in St. Louis now think they know why.

Genetically engineered bacteria are sweet success against IBD

For the first time, scientists have used a genetically engineered "friendly" bacterium to deliver a therapy.

Evolution of the appendix: A biological 'remnant' no more

DURHAM, N.C. -- The lowly appendix, long-regarded as a useless evolutionary artifact, won newfound respect two years ago when researchers at Duke University Medical Center proposed that it actually serves a critical function. The appendix, they said, is a safe haven where good bacteria could hang out until they were needed to repopulate the gut after a nasty case of diarrhea, for example.

Increase in visceral fat during menopause linked with testosterone

In middle-aged women, visceral fat, more commonly called belly fat, is known to be a significant risk factor for cardiovascular disease, but what causes visceral fat to accumulate?

The culprit is likely not age, as is commonly believed, but the change in hormone balance that occurs during the menopause transition, according to researchers at Rush University Medical Center.

Friendly gut bacteria lend a hand to fight infection, UT Southwestern study suggests

DALLAS -- Aug. 19, 2009 -- Immunology researchers at UT Southwestern Medical Center have found that bacteria present in the human gut help initiate the body's defense mechanisms against Toxoplasma gondii, the parasite responsible for toxoplasmosis.

Study finds adverse effects in treatment for primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is an uncommon chronic liver disease characterized by progressive inflammation and destruction of the bile ducts. The disease progresses slowly, usually leading to biliary cirrhosis, portal hypertension and liver failure over a 10-15 year period.

Key feature of immune system survived in humans, other primates for 60 million years

CORVALLIS, Ore. -- A new study has concluded that one key part of the immune system, the ability of vitamin D to regulate anti-bactericidal proteins, is so important that is has been conserved through almost 60 million years of evolution and is shared only by primates, including humans -- but no other known animal species.

Fatigue related to radiotherapy may be caused by inflammation

PHILADELPHIA -- Patients who experience fatigue during radiotherapy for breast or prostate cancer may be reacting to activation of the proinflammatory cytokine network, a known inflammatory pathway, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.

Elevated arginase levels contribute to vascular eye disease such as diabetic retinopathy

AUGUSTA, Ga. - Elevated levels of the enzyme arginase contribute to vascular eye damage and Medical College of Georgia researchers say therapies to normalize its levels could halt progression of potentially blinding diseases such as diabetic retinopathy.

Inexpensive hypertension drug could be multiple sclerosis treatment, Stanford study shows

STANFORD, Calif. -- Turning serendipity into science, researchers at the Stanford University School of Medicine have found a link, in mice and in human brain tissue, between high blood pressure and multiple sclerosis. Their findings suggest that a safe, inexpensive drug already in wide use for high blood pressure may have therapeutic value in multiple sclerosis, as well.

Corticosteroid injections may be helpful to manage vocal fold polyps without surgery

Corticosteroid injections appear to offer an alternative to surgery for treating polyps on the vocal cords, according to a report in the August issue of Archives of Otolaryngology?Head & Neck Surgery, one of the JAMA/Archives journals.



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