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Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say

JACKSONVILLE, Fla. -- In a surprising reversal of long-standing scientific belief, researchers at the Mayo Clinic campus in Florida have discovered that inflammation in the brain is not the trigger that leads to buildup of amyloid deposits and development of Alzheimer's disease.

Phytochemicals in plant-based foods could help battle obesity, disease

GAINESVILLE -- The cheeseburger and French fries might look tempting, but eating a serving of broccoli or leafy greens first could help people battle metabolic processes that lead to obesity and heart disease, a new University of Florida study shows.

Stanford study identifies cellular mechanism that causes lupuslike symptoms in mice

STANFORD, Calif. -- Macrophages, the scavenger cells of the body's immune system, are responsible for disposing of dying cells. Stanford University School of Medicine researchers have identified one pathway in this important process in mice that, if disrupted, causes a lupuslike autoimmune disease.

New chromosomal abnormality identified in leukemia associated with Down syndrome

Researchers identified a new chromosomal abnormality in acute lymphoblastic leukemia (ALL) that appears to work in concert with another mutation to give rise to cancer. This latest anomaly is particularly common in children with Down syndrome.

New therapy for vasculitis will help patients avoid infertility and cancer

Researchers have identified that Rituxan, a drug previously approved for the treatment of non-Hodgkin's B cell lymphoma and rheumatoid arthritis, can treat severe ANCA-associated vasculitis as effectively as cyclophosphamide, the current standard therapy. The news will be presented October 18 at the annual meeting of the American College of Rheumatology in Philadelphia.

Lupus patients perceive benefit from cardiovascular disease prevention counseling program

According to a new study by Hospital for Special Surgery investigators presented at the American College of Rheumatology meeting on October 21 in Philadelphia, most lupus patients are not aware that their condition puts them at a higher risk for cardiovascular disease and a counseling program is a valuable way to promote education and lifestyle change.

Protein interaction network can respond Helicobacter pylori infection?

Helicobacter pylori (H pylori) is a gram negative bacterium which infects about 50% of the world population. H pylori colonization causes a strong systemic immune response. Various tools have been employed to identify the relationship between H pylori and gastric cancer, including c-DNA microarrays.

ID3 provides career counseling for blood progenitors, driving the creation of gamma-delta T cells

Like an unusually forceful career counselor, the Id3 protein decides the fate of a given white blood cell precursor, according to researchers at Fox Chase Cancer Center. Their findings, published today in the journal Immunity, describe how Id3 directs blood cell progenitors to become gamma-delta T cells.

Unusual bacteria help balance the immune system in mice

Medical researchers have long suspected that obscure bacteria living within the intestinal tract may help keep the human immune system in balance. An international collaboration co-led by scientists at NYU Langone Medical Center has now identified a bizarre-looking microbial species that can single-handedly spur the production of specialized immune cells in mice.

Treatment not testicular cancer poses greatest risk to survivors' long-term health

Testicular cancer survivors can face an increased risk of long-term illness, not because of the malignancy, but the highly effective treatment they receive, according to a study in the urology journal BJUI.

Scientists remove amyloid plaques from brains of live animals with Alzheimer's disease

A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaques -- considered a hallmark of the disease -- from patients' brains.

UT Southwestern study shows how substance in grapes may squeeze out diabetes

DALLAS -- Oct. 15, 2009 -- A naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet.

Important defense against stomach ulcer bacterium identified

A special protein in the lining of the stomach has been shown to be an important part of the body's defense against the stomach ulcer bacterium Helicobacter pylori in a new study from the Sahlgrenska Academy at the University of Gothenburg. The discovery may explain why the bacterium makes some people more ill than others.

UF researchers find triggers in cells' transition from colitis to cancer

GAINESVILLE, Fla. -- University of Florida researchers have grown tumors in mice using cells from inflamed but noncancerous colon tissue taken from human patients, a finding that sheds new light on colon cancer and how it might be prevented.

Discovery of genetic defect may lead to better treatments for common gut diseases

INDIANAPOLIS -- New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract.



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