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How to improve vaccines to trigger T cell as well as antibody response

Killed or disabled viruses have proven safe and effective for vaccinating billions worldwide against smallpox, polio, measles, influenza and many other diseases.

But killed or severely "attenuated" vaccines, which are safer than "live" vaccines, have been largely unsuccessful for many non-viral diseases, including illnesses like tuberculosis and malaria.

Researchers induce HIV-neutralizing antibodies that recognize HIV-1 envelope protein, lipids

(Rockville, MD) -- For the first time, researchers have experimentally induced antibodies that neutralize HIV-1 and simultaneously recognize both HIV-1 envelope protein and lipids. The results were reported by U.S. Military HIV Research Program (MHRP) researchers on Aug. 25 in the online version of AIDS, the official journal of the International AIDS Society.

High HIV infection rate among Soweto Township gays

New research from UCSF examining HIV among men who have sex with men (MSM) in the township of Soweto in South Africa has found that a third of gay-identified men are infected with HIV.

HIV subtype linked to increased likelihood for dementia

Patients infected with a particular subtype of HIV, the virus that causes AIDS, are more likely to develop dementia than patients with other subtypes, a study led by Johns Hopkins researchers shows.

Working too much can be dangerous for teen's sexual health

ANN ARBOR, Mich.---Allowing teens to work too many hours in the wrong environment can be dangerous for their sexual health by fostering conditions that lead them to older sex partners, a new study shows.

Tips from the journals of the American Society for Microbiology

Organic and Natural Beef Cattle Production Systems Offer No Major Difference in Antibiotic Susceptibility of E. coli

A new 'bent' on fusion

MADISON -- Success in soccer sometimes comes with "bending it like Beckham." Success in cellular fusion -- as occurs at the moment of conception and when nerve cells exchange neurotransmitters -- requires that a membrane be bent before the merging process can begin, University of Wisconsin-Madison researchers have shown.

Engineered protein-like molecule protects cells against HIV infection

MADISON -- With the help of the human immunodeficiency virus (HIV) and molecular engineering, researchers have designed synthetic protein-like mimics convincing enough to interrupt unwanted biological conversations between cells.

Needle-free, inhalant powder measles vaccine could save thousands of lives

WASHINGTON, Aug. 16, 2009 -- The first dry powder inhalable vaccine for measles is moving toward clinical trials next year in India, where the disease still sickens millions of infants and children and kills almost 200,000 annually, according to a report presented here today at the 238th National Meeting of the American Chemical Society (ACS).

Updated guidelines highlight primary care needs of those living with HIV

Arlington, Va. -- With HIV patients living longer thanks to advances in treatment, the primary care needs of those living with HIV have never been more important. Updated, evidence-based guidelines from the HIV Medicine Association (HIVMA) and the Infectious Diseases Society of America (IDSA) are designed to help providers manage the care of those living with this complex chronic infection.

An HIV-blocking gel for women

SALT LAKE CITY, Aug. 10, 2009 -- University of Utah scientists developed a new kind of "molecular condom" to protect women from AIDS in Africa and other impoverished areas. Before sex, women would insert a vaginal gel that turns semisolid in the presence of semen, trapping AIDS virus particles in a microscopic mesh so they can't infect vaginal cells.

Yerkes researchers propose ambitious new strategies for AIDS vaccine research

Researchers at the Yerkes National Primate Research Center, Emory University, believe conventional vaccine strategies should not be the only avenue explored in the development of an effective AIDS vaccine.

Wistar scientists find key to strengthening immune response to chronic infection

PHILADELPHIA -- (August 6, 2009) -- A team of researchers from The Wistar Institute has identified a protein that could serve as a target for reprogramming immune system cells exhausted by exposure to chronic viral infection into more effective "soldiers" against certain viruses like HIV, hepatitis C, and hepatitis B, as well as some cancers, such as melanoma.

Scientists report original source of malaria

Irvine, Calif. -- Researchers have identified what they believe is the original source of malignant malaria: a parasite found in chimpanzees in equatorial Africa.

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

A member of a new class of antiretroviral drugs is safe and effective for patients beginning treatment against HIV, according to researchers who have completed a two-year multisite phase III clinical trial comparing it with standard antiretroviral drugs.

The results are online and scheduled for publication in an upcoming issue of the Lancet.



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