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The beginning of the end for HIV/AIDS? The RV144 HIV Vaccine trial in Thailand reports success

September 24, 2009 by BlueGenes

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When HIV was discovered as the causative agent of AIDS in 1984 (and has since been repeatedly proven, despite denialists claims - see Ben's post) scientists were relieved: "It's a virus! Phew, viruses are something we can deal with. Alright, somebody go cook up a vaccine: problem solved". According to wikipedia, senior figures in the US health system claimed that a vaccine would be ready in as little as two years. 25 years later HIV is getting the better of us like no other disease, and the vaccine front has seen failure after failure. Continue reading for a brief analysis of the latest HIV vaccine study: even better continue reading at Blue-Genes.net where this post was born and bred.

HIV vaccine regimen demonstrates modest preventive effect in Thailand clinical study

In an encouraging development, an investigational vaccine regimen has been shown to be well-tolerated and to have a modest effect in preventing HIV infection in a clinical trial involving more than 16,000 adult participants in Thailand. Following a final analysis of the trial data, the Surgeon General of the U.S.

New chemically-activated antigen could expedite development of HIV vaccine

Scientists working to develop a vaccine for the human immunodeficiency virus (HIV) report they have created the first antigen that induces protective antibodies capable of blocking infection of human cells by genetically-diverse strains of HIV.

HIV uses several strategies to escape immune pressure

ATLANTA - A study of how HIV mutates in response to immune system pressure by Emory Vaccine Center researchers shows that the virus can take several escape routes, not one preferred route.

The results are online and scheduled for publication in the September issue of the journal Public Library of Science Pathogens.

Weighing costs, benefits of HIV treatments

HANOVER, NH -- Prevention versus treatment? Cost versus efficacy? So go two of the dilemmas looming over Dartmouth's Paul E. Palumbo, M.D., and his fellow researchers in the race to fight HIV and other infectious diseases in the developing world -- especially among women and their young children.

Once-daily pill effective as multiple dosings for oral yeast infection in HIV/AIDS patients

DETROIT -- A once-daily medication option for treating the most common mouth infection in HIV/AIDS patients has shown to be just as effective and safe as taking an anti-fungal pill five times a day, according to a Henry Ford Hospital study.

Virus responsible for deadly brain disease found in MS patients treated with natalizumab

BOSTON -- The virus responsible for PML (progressive multifocal leukoencephalopathy), a rare brain disease that typically affects AIDS patients and other individuals with compromised immune systems, has been found to be reactivated in multiple-sclerosis patients being treated with natalizumab (Tysabri).

UAB researchers find TB-prevention therapy is cost-effective option

BIRMINGHAM, Ala. -- University of Alabama at Birmingham (UAB) researchers have found that the cost of preventive antibiotic tuberculosis (TB) therapy for patients infected by human immunodeficiency virus (HIV) is generally less expensive than the reported cost of treating newly confirmed TB cases.

Discovery leads to rapid mouse 'personalized trials' in breast cancer

DURHAM, N.C. -- One person's breast cancer is not the same as another person's, because the gene mutations differ in each tumor. That makes it difficult to match the best therapy with the individual patient.

Safe seed: Researchers yielding good results on food cotton in field

Field trials of a new cotton are verifying previous lab and greenhouse studies indicating the crop could become a source of protein for millions of malnourished people in the world.

The cotton was engineered so that the toxic gossypol is reduced to tolerable levels in the high-protein seed but remain at higher levels in the rest of the plant to ward off pests and disease.

How to improve vaccines to trigger T cell as well as antibody response

Killed or disabled viruses have proven safe and effective for vaccinating billions worldwide against smallpox, polio, measles, influenza and many other diseases.

But killed or severely "attenuated" vaccines, which are safer than "live" vaccines, have been largely unsuccessful for many non-viral diseases, including illnesses like tuberculosis and malaria.

Researchers induce HIV-neutralizing antibodies that recognize HIV-1 envelope protein, lipids

(Rockville, MD) -- For the first time, researchers have experimentally induced antibodies that neutralize HIV-1 and simultaneously recognize both HIV-1 envelope protein and lipids. The results were reported by U.S. Military HIV Research Program (MHRP) researchers on Aug. 25 in the online version of AIDS, the official journal of the International AIDS Society.

High HIV infection rate among Soweto Township gays

New research from UCSF examining HIV among men who have sex with men (MSM) in the township of Soweto in South Africa has found that a third of gay-identified men are infected with HIV.

HIV subtype linked to increased likelihood for dementia

Patients infected with a particular subtype of HIV, the virus that causes AIDS, are more likely to develop dementia than patients with other subtypes, a study led by Johns Hopkins researchers shows.

Working too much can be dangerous for teen's sexual health

ANN ARBOR, Mich.---Allowing teens to work too many hours in the wrong environment can be dangerous for their sexual health by fostering conditions that lead them to older sex partners, a new study shows.



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