Glioblastoma multiforme
RICHMOND, Va. (Nov. 20, 2009) -- Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Let me begin this blog with “I do not know” whether cell phone used causes brain cancer in the form of tumors or not. However, not knowing something means you do not know and hence caution is most likely in order, particularly when cancer is the point of discussion.
BOSTON (August 10, 2009) -- In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation.
Two forms of skin and brain cancer respond very poorly to chemotherapy and radiation: melanoma and glioblastoma multiforme brain cancer.
LOS ANGELES (STRICTLY EMBARGOED UNTIL 12:01 A.M. EDT on JULY 1, 2009) -- A specific biomarker, a protein released by dying tumor cells, has been identified as an effective tool in an animal model to gauge the response to a novel gene therapy treatment for glioblastoma mulitforme.
ANN ARBOR, Mich. -- University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early.
ANN ARBOR, Mich. ? University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early.
PHOENIX, Ariz. - April 17, 2009 - Researchers at the Translational Genomics Research Institute (TGen) may have found a way to stop the often-rapid spread of deadly brain tumors.
CHAPEL HILL - Researchers at the University of North Carolina at Chapel Hill School of Medicine have identified a compound that could be modified to treat one of the most deadly types of cancer, and discovered how a particular gene mutation contributes to tumor growth.
Despite aggressive treatment, glioblastoma multiforme (GBM) ? the most common and deadly of brain cancers ? usually claims the lives of its victims within six to 12 months of diagnosis. This statistic has changed little over the years, largely because the cancer grows so quickly that neither surgery, radiation, or chemotherapy can stop it. Now, researchers at Cedars-Sinai Medical Center have found that a small protein called hsFlt3L delivered via a genetically engineered virus increased the number of immune cells in the brain and significantly slowed tumor growth, increasing the survival of laboratory rats in pre-clinical studies. The study, published in the December issue of the journal, Molecular Therapy, may lead to a new way to treat patients with GBM.
Cannabinoids, the active ingredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF). According to a new study, administration of cannabinoids significantly lowered VEGF activity in laboratory mice and two patients with late-stage glioblastoma.
Frederick Hawthorne and the history of boron chemistry go hand in hand. Hawthorne helped create the field in the 1950s, and has done more than anyone to show the fifth element's utility, for everything from rocket fuel to pharmaceuticals. Along the way he has garnered nearly every accolade a scientist can, including the 2003 King Faisal Award. It is medicine -- and cancer treatment specifically -- that has Hawthorne embarking now on a new venture in collaboration with his employer, UCLA. Together Hawthorne and the University are creating a foundation to develop an obscure, but potentially revolutionary way to treat tumors. Known as Boron Neutron Capture Therapy (BNCT), it puts to use decades-old theory to selectively destroy cancer through small nuclear explosions at the cellular level.
Researchers in Los Angeles have combined a special protein that targets cancer cells with neural stem cells to track and attack malignant brain tumor cells. Glioblastoma multiforme, or gliomas, are a particularly deadly type of brain tumor. They are highly invasive with poorly defined borders that intermingle with healthy brain tissue, making them nearly impossible to remove surgically without catastrophic consequences. Furthermore, cells separate from the main tumor and migrate to form satellites that escape treatment and often lead to recurrence.
