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Diabetes drug kills cancer stem cells in combination treatment in mice

BOSTON, Mass. (September 14, 2009) -- In a one-two punch, a familiar diabetes drug reduced tumors faster and prolonged remission in mice longer than chemotherapy alone, apparently by targeting cancer stem cells, report Harvard Medical School researchers in the Sept. 14 advance online Cancer Research.

Information about the use and accuracy of breast cancer tests is lacking, study finds

A new study finds that there is little information available about the use of new testing technologies and targeted therapies in breast cancer, specifically the anti-cancer drug trastuzumab (Herceptin).

How stem cells make skin

Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.

University of Hawaii at Manoa CRCH scientists report adulthood body size associated with cancer risk

A team of scientists led by researcher Brenda Hernandez, Ph.D., M.P.H. -- an assistant professor at the University of Hawai'i at Mānoa's Cancer Research Center of Hawai'i -- has reported that body mass in younger and older adulthood, and weight gain between these life periods, may influence a man's risk for prostate cancer.

No change in the link between deprivation and death since 1900s

The link between deprivation and premature death is as strong today as it was in the early 1900s according to research published on bmj.com today.

Worldwide isotope shortage continues to pose significant challenges

RESTON, Va. -- SNM recently conducted a survey of nuclear pharmacies -- pharmacies that supply the critical radioisotope Technetium-99m, which is used in more than 16 million nuclear medicine tests each year in the United States -- to assess, anecdotally, the impact of the worldwide medical isotope shortage.

Overexpressed protein converts noninvasive breast cancer into invasive disease

HOUSTON ― Active, but non-invasive breast cancer is set free to roam as invasive breast cancer when an overexpressed protein converts it to a different cell type, scientists at The University of Texas M. D. Anderson Cancer Center report in the Sept. 9 issue of the journal Cancer Cell.

Mayo Clinic researchers find lung cancer oncogene holds key to turning off cancer stem cells

JACKSONVILLE, Fla. -- Scientists at the Mayo Clinic campus in Florida have found that the lung cancer oncogene PKCiota is necessary for the proliferation of lung cancer stem cells. These stem cells are rare and powerful master cells that manufacture the other cells that make up lung tumors and are resistant to chemotherapy treatment.

Even in a safety net health system, colorectal cancer screening disparities remain

PHILADELPHIA -- Colorectal cancer screening rates are much lower among those in a safety net health system compared to the national average, and the number one predictor of screening is a combination of regular visits and insurance access.

Researchers find first evidence of virus in malignant prostate cells

(SALT LAKE CITY) -- In a finding with potentially major implications for identifying a viral cause of prostate cancer, researchers at the University of Utah and Columbia University medical schools have reported that a type of virus known to cause leukemia and sarcomas in animals has been found for the first time in malignant human prostate cancer cells.

Malignant signature may help identify patients likely to respond to therapy

A molecular signature that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a particular anti-cancer drug.

Discovery leads to rapid mouse 'personalized trials' in breast cancer

DURHAM, N.C. -- One person's breast cancer is not the same as another person's, because the gene mutations differ in each tumor. That makes it difficult to match the best therapy with the individual patient.

New research strategy for understanding drug resistance in leukemia

UCSF researchers have developed a new approach to identify specific genes that influence how cancer cells respond to drugs and how they become resistant.

Mayo Clinic researchers find that protein believed to protect against cancer has a Mr. Hyde side

JACKSONVILLE, Fla. -- In a biological rendition of fiction's Strange Case of Dr. Jekyll and Mr. Hyde, researchers from the Mayo Clinic campus in Florida and Harvard Medical School have found that a protein thought to protect against cancer development can actually spur the spread of tumors.

HPV vaccine could prevent breast cancer: Australian research

Vaccinating women against the human papillomavirus (HPV) may prevent some forms of breast cancer and save tens of thousands of lives each year, new Australian research suggests.



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