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KEAP1 Keeps major cancer-promoting protein at bay

HOUSTON - A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell.

Vaccinating boys against human papillomavirus not cost-effective

Boston, MA -- Persistent infection with high-risk types of human papillomavirus (HPV), a sexually transmitted virus, is known to be a cause of cervical cancer. Current guidelines prioritize HPV vaccination of pre-adolescent girls, which has been shown to be cost-effective in previous studies, but the value of vaccinating boys in the United States has been unclear.

Survivors of childhood cancer less likely to marry

PHILADELPHIA -- Childhood cancer survivors typically suffer from the long-term effects of cancer treatment on physical health, and results of a new study suggest that social implications also exist, which may affect their chance of an "I do" at the altar.

African American lung cancer patients may have different response to new cancer-fighting drugs

Clinical research out of University Hospitals Case Medical Center has found that African Americans with a common form of lung cancer have a lower frequency of drug-sensitizing genetic mutations, which may impact response to new cancer-fighting drugs.

Genes signal late-stage laryngeal cancer, poorer outcome

SAN DIEGO -- Researchers at Henry Ford Hospital have identified tumor-suppressing genes that may provide a more accurate diagnosis of disease stage and survival for laryngeal cancer patients than current standards.

New treatment more than doubles survival for high risk childhood leukemia

Results of a phase two clinical trial published October 5th in the Journal of Clinical Oncology show that adding continuous daily doses of a targeted drug called imatinib mesylate to regular chemotherapy more than doubled three-year survival rates for children with a high risk type of blood cancer called Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

High-sensitivity bone marrow aspiration technology enhances leukemia cell detection

PHILADELPHIA -- Scientists have created a viable technology to improve the detection of leukemia cells in bone marrow.

Physical activity in adolescence associated with decreased risk of brain cancer in adulthood

PHILADELPHIA -- While little is known about the causes of glioma, researchers at the National Cancer Institute have found that this rare but often deadly form of brain cancer may be linked to early life physical activity and height.

Stereotactic radiosurgery preferred method of treating cancer patients with brain metastases

HOUSTON -- Cancer patients who receive stereotactic radiosurgery (SRS) and whole brain radiation therapy (WBRT) for the treatment of metastatic brain tumors have more than twice the risk of developing learning and memory problems than those treated with SRS alone, according to researchers at The University of Texas M. D. Anderson Cancer Center.

Many childhood cancer survivors have uncomplicated pregnancies, healthy babies

Women who survived cancer in childhood or adolescence or women whose male partner is a childhood cancer survivor do not appear to have an increased risk of major complications during pregnancy, having babies with birth defects or infant deaths, according to two reports in the October issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

Inventive combination of research approaches identifies new target for treating leukemia

New research integrates sophisticated interdisciplinary approaches to solve a molecular mystery that may lead to alternative therapeutic strategies for acute myeloid leukemia (AML).

Wistar researchers identify gene that regulates breast cancer metastasis

PHILADELPHIA -- (October 5, 2009) -- Researchers at The Wistar Institute have identified a key gene (KLF17) involved in the spread of breast cancer throughout the body. They also demonstrated that expression of KLF17 together with another gene (Id1) known to regulate breast cancer metastasis accurately predicts whether the disease will spread to the lymph nodes.

DNA test could be key to targeting treatments for head and neck cancer

It is estimated that more than 7,000 people are diagnosed with head and neck cancer each year in the UK and approximately 3,500 cases result in death. These cancers include tumours of the mouth, lips, throat and voice-box, and some have been linked to the sexually transmitted infection, HPV-16.

Curcumin may inhibit nicotine-induced activation of head and neck cancers

San Diego, CA -- Curcumin, the compound that gives curry powder its yellow/orange color, may inhibit the adverse effects of nicotine in patients with head and neck cancer who continue to smoke.

Study finds 231 new genes associated with head and neck cancer

SAN DIEGO -- A Henry Ford Hospital study has identified 231 new genes associated with head and neck cancer, one of the most deadly cancers responsible for 2.1 percent of all cancer deaths in the United States.

Previously, only 33 genes were reported associated with head and neck cancer.



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