Alcoholism
Despite widespread warnings about the potential risk of drinking alcohol during pregnancy, fifteen percent of pregnant women in a newly published study said they had drunk alcohol at least once during their pregnancies. And although most of those women reported on an anonymous survey that they'd had less than one drink a week, some acknowledged drinking more than that on a regular basis, or said they'd had at least one binge of five or more drinks at once.
U.S. government scientists have demonstrated that a miniature positron emission tomography (PET) scanner, known as microPET, and the chemical markers used in traditional PET scanning are sensitive enough to pick up subtle differences in neurochemistry between known genetic variants of mice. This "proof-of-principle" experiment "opens up a whole new, non-invasive way to study and follow transgenic or genetically engineered strains of mice that serve as animal models for human neurological diseases, such as Parkinson's and Alzheimer's disease or psychiatric diseases such as substance abuse, depression, and anxiety disorders," said Panayotis (Peter) Thanos, lead author of the study.
The hunt to find a gene that causes a disease typically costs hundreds of thousands of dollars and requires years of research - and it still may fail to turn up the sought-after culprit, driving the research back to square one. The result is that while the genes involved in a few inherited diseases such as cystic fibrosis have been identified, many have not. Now, two scientists say they may have found a way to make the search more economical and speed it up. In an article to appear online in the Proceedings of the National Academy of Sciences next week, scientists from the University of Florida and Purdue University report merging two established genetic-screening techniques to create one that's better. The new technique narrows the pool of "candidate" genes in a study from thousands of possibilities to fewer than 100 - perhaps as few as 20.
