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The ends of mRNAs may prevent the beginnings of cancer

CAMBRIDGE, Mass. (August 20, 2009) -- The tail ends of cellular protein templates, regions often thought relatively inconsequential, may actually play a role in preventing normal cells from becoming cancerous.

The finding from scientists at Whitehead Institute for Biomedical research is reported in the August 20 edition of Cell.

Newly discovered mechanism in cell division has implications for chromosome's role in cancer

PHILADELPHIA -- "A biologist, a physicist, and a nanotechnologist walk into a ..." sounds like the start of a joke. Instead, it was the start of a collaboration that has helped to decipher a critical, but so far largely unstudied, phase of how cells divide.

Math model accurately mimics cell division in carbon-cycling bacterium

Blacksburg, Va. -- Scientists from the Department of Biological Sciences and the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a quantitative, mathematical model of DNA replication and cell division for the bacterium Caulobacter crescentus. C.

Raising the alarm when DNA goes bad

Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases.

First human gene implicated in regulating length of human sleep

Scientists have discovered the first gene involved in regulating the optimal length of human sleep, offering a window into a key aspect of slumber, an enigmatic phenomenon that is critical to human physical and mental health.

Technique enables efficient gene splicing in human embryonic stem cells

p>CAMBRIDGE, Mass. (August 13, 2009) -- A novel technique allows researchers to efficiently and precisely modify or introduce genes into the genomes of human embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, according to Whitehead scientists.

Protein plays unexpected role protecting chromosome tips

HOUSTON - A protein specialist that opens the genomic door for DNA repair and gene expression also turns out to be a multi-tasking workhorse that protects the tips of chromosomes and dabbles in a protein-destruction complex, a team lead by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Aug. 13 edition of Molecular Cell.

Researchers identify potential new avenue to attack cancer

EAST LANSING, Mich. -- New insight into how human cells reproduce, published by cancer researchers at Michigan State University and the Van Andel Research Institute in Grand Rapids, could help scientists move closer to finding an "off switch" for cancer.

Discovery may lead to powerful new therapy for asthma

GALVESTON, Texas -- University of Texas Medical Branch at Galveston researchers have found that a single enzyme is apparently critical to most allergen-provoked asthma attacks -- and that activity of the enzyme, known as aldose reductase, can be significantly reduced by compounds that have already undergone clinical trials as treatments for complications of diabetes.

Scripps Research scientists find early evolution maximized the 'spellchecking' of protein sequences

LA JOLLA, CA -- August 5, 2009 ?As letters of the alphabet spell out words, when amino acids are linked to one another in a particular order they "spell out" proteins. But sometimes the cell machinery for building proteins in our bodies makes a mistake and the wrong amino acid is inserted.

Earth's biogeochemical cycles, once in concert, falling out of sync

What do the Gulf of Mexico's "dead zone," global climate change, and acid rain have in common?

UC San Diego engineer provides insights to decades-old DNA squabble

A group of nanoengineers, biologists and physicists have used innovative approaches to deduce the internal structure of chromatin, a key player in DNA regulation, to reconcile a longstanding controversy in this field. This new finding could unlock the mystery behind the origin of many diseases such as cancer.

Nanotubes take flight

With products that range from carpets to kites, you'd think Rice University chemist Bob Hauge was running a department store.

What he's really running is a revolution in the world of carbon nanotechnology.

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

Philadelphia (July 27, 2009) -- DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-cancer drugs, they reason.

Stress signals link pre-existing sickness with susceptibility to bacterial infection

Mitochondrial diseases disrupt the power generating machinery within cells and increase a person's susceptibility to bacterial infection, particularly in the lungs or respiratory tract.



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