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Researchers identify role of gene in tumor development, growth and progression

RICHMOND, Va. (Nov. 20, 2009) -- Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.

Duke develops nano-scale drug delivery for chemotherapy

DURHAM, N.C. -- Going smaller could bring better results, especially when it comes to cancer-fighting drugs.

Mice regain ability to extend telomeres suggesting potential for dyskeratosis congenita therapy

The human genetic disease dyskeratosis congenita (DKC) is an autosomal dominant disease that leads to abnormalities in tissues with a rapid cell turnover -- the skin, nails, bone marrow, lungs and gut. Patients with DKC experience life-threatening symptoms. Bone marrow failure increases their risk of fatal infections and cancer.

Loss of tumor-suppressor and DNA-maintenance proteins causes tissue demise

PHILADELPHIA - A study published in the October issue of Nature Genetics demonstrates that loss of the tumor-suppressor protein p53, coupled with elimination of the DNA-maintenance protein ATR, severely disrupts tissue maintenance in mice. As a result, tissues deteriorate rapidly, which is generally fatal in these animals.

Survivors of childhood cancer less likely to marry

PHILADELPHIA -- Childhood cancer survivors typically suffer from the long-term effects of cancer treatment on physical health, and results of a new study suggest that social implications also exist, which may affect their chance of an "I do" at the altar.

Penn studies point to strategies for reducing painful breast cancer drug side effects

(PHILADELPHIA) -- Aromatase inhibitors, the same drugs that have buoyed long-term survival rates among breast cancer patients, also carry side effects including joint pain so severe that many patients discontinue these lifesaving medicines.

New cancer drug test promises safer and more effective clinical trials

Berlin, Germany: A group of scientists from Hamburg may have taken a big step towards more effective cancer drug development, Europe's largest cancer congress, ECCO 15 -- ESMO 34 [1], heard today (Wednesday 23 September).

Therapeutic nanoparticles give new meaning to sugar-coating medicine

A research team at the National Institute of Standards and Technology (NIST) studying sugar-coated nanoparticles for use as a possible cancer therapy has uncovered a delicate balancing act that makes the particles more effective than conventional thinking says they should be.

Casting out devils

In the scientific journal PLoS ONE, Sara Bartels and Siegfried Weiss of the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany now show how the bacteria migrate into tumours. A messenger substance from the immune system is the door opener: It makes blood vessels in the cancerous tissue permeable; enabling the bacteria to conquer and destroy the tumour.

Natural compounds, chemotherapeutic drugs may become partners in cancer therapy

CORVALLIS, Ore. -- Research in the Linus Pauling Institute at Oregon State University suggests that some natural food compounds, which previously have been studied for their ability to prevent cancer, may be able to play a more significant role in treating it -- working side-by-side with the conventional drugs that are now used in chemotherapy.

'Hedgehog' pathway may hold key to anti-cancer therapy

Scientists in Switzerland have discovered a way to block the growth of human colon cancer cells, preventing the disease from reaching advanced stages and the development of liver metastases.

Study finds promise in combined transplant/vaccine therapy for high-risk leukemia

BOSTON--Two of the most powerful approaches to cancer treatment -- a stem cell transplant and an immune system-stimulating vaccine -- appear to reinforce each other in patients with an aggressive, hard-to-control form of leukemia, Dana-Farber Cancer Institute scientists have found.

Study supports DNA repair-blocker research in cancer therapy

BOSTON--Scientists at Dana-Farber Cancer Institute have uncovered the mechanism behind a promising new approach to cancer treatment: damaging cancer cells' DNA with potent drugs while simultaneously preventing the cells from repairing themselves.



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