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Does OTC diet pill Alli live up to its name?

The first and only over-the-counter product for weight loss approved by the Food and Drug Administration will be available Friday, June 15.

Orlistat, known by the brand name Alli, works by decreasing the amount of fat absorbed by the body. It is the OTC version of Xenical, a prescription weight loss pill. The good news: Orlistat has been tested and the prescription version has been used since 1999.

Last fall Dr. James Anderson, head of the UK College of Medicine Metabolic Research Group, and his colleagues examined the effects of OTC strength (60 mg) orlistat on mildly to moderately overweight individuals. The study was the first of its kind. Previously, the drug's effects had only been studied in obese individuals. Study participants took either orlistat or a placebo three times daily with meals for 16 weeks. Results of that study showed those taking OTC-strength orlistat did lose more weight than those taking the placebo.

"Our research showed that people taking orlistat and following low-fat diets lost almost five percent of their initial body weight, about seven to15 pounds, over four months," Anderson said. "While two to four pounds a month isn't dramatic, steady weight loss of this amount can have major health benefits. For example, the reduction in LDL-cholesterol, the bad-guy cholesterol, of 10 percent can reduce risk of heart attack by 20 percent."

Any successful dieter knows that long-term weight loss is about lifestyle changes not quick fixes. While taking Alli may help you lose weight, it won't do all of the work for you. Anderson stresses a healthy diet and exercise plan are absolutely necessary to lose the weight and keep it off.

"This is the first over-the-counter medicine that has proven effectiveness. It is my hope that people will take one capsule before each regular meal, breakfast, lunch, and supper, and alter their fat and calorie intake," Anderson said. "If they commit to exercise six days a week, most people can lose weight steadily. All of us are in this for the long haul and need to keep up healthy behaviors, not for days or weeks, but for months and years. Doing regular physical activity and making good food choices will help us be trimmer and give us more energy."

http://www.uky.edu


June 13, 2007

Comments

happend to me too

October 13, 2009 by Anonymous, 6 weeks 6 days ago
Comment: 45431

happend to me too

Well that means you are

September 21, 2009 by Anonymous, 10 weeks 20 hours ago
Comment: 44882

Well that means you are eating bullshit honey! if you don't eat fat, you can't poo fat ...

On Alli for 30 days...

September 18, 2009 by Anonymous, 10 weeks 3 days ago
Comment: 44832

I agree to comment id: 33173.

I also believe that some people here will not experience complete success. Seems they take the pill only when it’s convenient or when they can shit themselves in private!!! :S
This is the wrong way to think!

You need to seriously adjust the way you eat. This way the pill can be taken, as recommended, 3 times a day.
Oil may still appear in your stool but with a meal under 15 grams of fat, you SHOULD NOT have uncontrollable diarrhea!
If you are shitting your pants after every meal...you need to think long and hard about what you are putting in your mouth!

I've been on Alli for about 30 days now and haven't experience a single embarrasing poopy pants accident!
I've lost 2 lbs so far and have been eating better and exercising 3 days a week.
It's not only the weight loss that has me excited; it's understanding how to eat right and live healthier!

Good luck to all out there trying this and please keep my advice in mind.
If you are concerned about diarrhea after a fatty meal – don’t avoid the pill, avoid the fatty meal!!!

Oil

September 6, 2009 by Anonymous, 12 weeks 1 day ago
Comment: 44626

Used Alli for about a week now, not obese just looking to lose a few baby lbs. OMG !! Oil ! Better out than in though ! I've learned, I only take it when I'm home. I had an incident of oil spotting ! If I had been at work I'd have been pissed !! Luckly I was home. I only take them at night, or in the afternoon after work. Those afraid of side effects should try that. Good Luck.

Too many weightloss drugs!

August 31, 2009 by Anonymous, 13 weeks 7 hours ago
Comment: 44472

There are so many weightloss drugs out there I don't know which one to believe in anymore!

low fat diets dont work..

July 12, 2009 by Anonymous, 20 weeks 1 day ago
Comment: 37921

yes low fat diets cause constipation.. all bran flakes is poser fiber go for the buds and drink plenty of water.. dont eat white flours of any kind.... eat lots of flax seed as it is very effective on the bowels... eat a few tablespoons of whole flax everyday with a probiaotic/prebiotic yogurt doing just those thing will shed the weight.. as it will clean your bowels and cravings will stop as you will be able to absorb more vitamins and minerals.. stop taking senna its taxing on the large intestine

6 lb loss

June 26, 2009 by Anonymous, 22 weeks 3 days ago
Comment: 37553

hey thats great you lost 6lb in 2 wks i lost 3lb on my 1st wk, in my second wk now... thats with not really been on a diet, and my exercise is work!! im happy with the alli there learnin me too eat more healhty to eat less fat etc!! as only gettin runny oily leakage down your leg other wise and need a pad constant if dont eat less fat!!!

so its a great help!! Mags x

poo

May 30, 2009 by Anonymous, 26 weeks 2 days ago
Comment: 36927

I lost 6 pounds in 2 weeks but can't stop pooing
I thought I needed to fart and blasted oily poop all over my underwear!

alli and constipation ?

May 20, 2009 by Anonymous, 27 weeks 5 days ago
Comment: 36758

Hello , i am a 47 year old male who has been taking alli for two weeks , ive stook to a healthy low diet for a few months and especially so with alli . I eat bran flakes . wholemeal
bread low filling's but my problem although long term and even more so with alli is constipation , i take movicol powder , senna tablets but not even alli move's me ? Any suggestions ? will adding a little more fat help maybe my diet is too low for alli too work ? Thanks

Constipation

May 12, 2009 by Anonymous, 28 weeks 6 days ago
Comment: 36606

YES! I also noticed the constipation is gone! I know of several people on similar prescribed meds as I am and one of the huge side effects is constipation. Within 3 days of starting Alli, I immediately noticed a change in bowel movements...for the better! I believe since I was very constipated prior to starting Alli, the fat that is eliminated with the bowel movement, makes me 'regular'...hence no horrible or embarrassing side effects!!!

2 months and counting

April 2, 2009 by Anonymous, 34 weeks 4 days ago
Comment: 35794

I am a 48 year old woman, 5'2", and my starting weight was 192 lbs. In early Feb. I decided I needed to do something about my weight.....for my own good, so I thought I'd try Alli. I am now down to 173! Sure, I am eating right (mostly) and exercising, but I do believe Alli has helped. I've dealt with the cause effects a little bit and it hasn't been too bad. All you have to do is just remember to not eat so much fat. It's not that difficult. I am overall pleased with Alli and would recommend it to anyone who is really ready. If you're not willing to give up the fat and calories then you aren't ready for Alli. Good luck to everyone.

LT

alli works great for constipation

March 31, 2009 by Anonymous, 34 weeks 6 days ago
Comment: 35724

I've been constipated all my life. After starting Alli and eating a meal with some fat twice a day, I am no longer constipated. No longer taking laxatives or stool softners which never worked. I go to the bathroom regularly without diarhea.

Alli Works

February 26, 2009 by Anonymous, 39 weeks 4 days ago
Comment: 34859

I'm a "middle aged" male who started Alli on February 2, 2008. I was on it for 9 weeks and lost 27 lbs - going from 193 to 166. Since then I've fluctuated from 163 to 170 - today at 168. It is a miracle drug. The bonus was the increased energy. Yes, I work out on an elliptical four or five times a week and I try not to be too stupid about what I eat. But those were pounds I'd tried to lose for 5 years.

I think the success to the program is that the "treatment effects" force you to eat right or else. It's like having a 24 hour nutritionist on staff. If you don't follow the guidelines, you might pay for it, so it's better to just follow the program. And besides, if you don't follow the guidelines, why waste money on the pill? The other reason it worked for me is, as one who loves to eat, I wasn't needing to watch calories and food intake so much, only fat grams. So as long as I ate the right things - low fat - the quantity was not as important.

I never thought I'd try a diet pill but I'm glad I did and I can't recommend it highly enough.

Alli worked for me

February 26, 2009 by Anonymous, 39 weeks 4 days ago
Comment: 34854

I first heard of Alli when my brother started taking it a year ago. He probably only used it for about two weeks and I personally didn't see any results. Well about five months ago I gave birth and while pregnant I didn't gain any weight. But, as soon as I stopped breast feeding I gained a horrifying 20 pounds. I went out and bought a bunch of exercise equipment even a pilates kit but nothing seem to help. I finally decided after I reached the 170 mark and all my favorite jeans weren't fitting that I was going to try a diet pill. I went to CVS and asked the Pharmacist opinion on pills and he told me that Alli was the only FDA approved one. So even though it didn't work for my brother I decided to spend the 60 dollars for the starter kit and I bought a digital scale. Needless to say I started taking Alli on Feb. 23, 2009 and I weighted in at 170.0 Ibs and today which is Feb. 27, 2009 I weigh in at 165.6 Ibs. I haven't been exercising at all because I am a full time student and mother but I do plan to start. I have been on 1100 calories a day and eating only 10 grams of fat a meal (To avoid the bathroom situation which lucky I haven't encountered yet.) I snack on Special K Chocolate bits with skim milk between meals, and I bake everything. Also, I cut out soda and bought a bunch of bottled water and Crystal light to go packs. So after 4 days I can honestly say I am having great results with Alli and even learned some self control.

will be new to the alli pill in 3weeks'

February 9, 2009 by Anonymous, 42 weeks 6 hours ago
Comment: 34409

can you tell me about the stool problems i heard some people say to be carefull that you don't poop your pant's i cant afford for that to happen no way,so can you please explain your exp. to me, also can you share with me the gum that you have lost your 55lbs off of and congrad's on your accomplishments!!!!! please e-mail me @ plumdelicious38@yahoo.com thank's much for the warnining!!!!(yikes) (lol)

Alli weight loss drug

January 29, 2009 by Anonymous, 43 weeks 4 days ago
Comment: 34099

I am researching for a documentary looking at potential weight loss solutions. I'd like to hear your thoughts on the weight loss drug ALLI. Please contact me at: jharrison@corazonproductions.ca

What are some low fat meals to eat while on the Alli weight loss

January 22, 2009 by rodentinua, 44 weeks 4 days ago
Comment: 33904

I love to eat and I hate dieting. Is thtere anything low fat, filling, and god tasting to eat while on the Alli pill?

"a good gum that stops me feeling hungry"?!

January 4, 2009 by Anonymous, 47 weeks 1 day ago
Comment: 33612

can you share the name of this 'good gum'?!

Hunger suppressant vs. fat blocker

December 2, 2008 by Anonymous, 51 weeks 6 days ago
Comment: 33173

I think the major reason why people give up on alli is their misunderstanding of how the drug works. Alli is NOT a hunger suppressant. It never promises that you can eat whatever you want and control your appetite. It simply promises to block a percentage (25%) of the fat your body absorbs. Common sense would then lead one to realize that if your body is not absorbing that fat, it has to go SOMEWHERE. Whatever the body DOES NOT USE is eliminated as WASTE... hence, those of you who refuse to accept the fat that you need to cut down the fat intake dramatically will find yourselves in a very bad position eg. hovering over the toilet with oily crap running down your leg at the mall. Keep in mind as well, that will power is a major key to the success of this pill. YOU MUST be WILLING to NOT eat the FAT! Why? Alli IS NOT a hunger suppressant. YOU must control your own hunger. Will power, exercise, right choices, low fat diet and plain old common sense will allow you to be successful at using Alli without side effects of any kind.

JUST STARTED TAKING THE ALLI PILLS

November 14, 2008 by Anonymous, 1 year 2 weeks ago
Comment: 32847

STARTED taking pills on 11-10-08.. i will give you an update of how its going...

Alli Diet

October 29, 2008 by Anonymous, 1 year 4 weeks ago
Comment: 32605

Hi, well I tried the Alli pills and I will not continue! I found a good gum that stops me feeling hungry. It's cheap and I have lost 55Lb now, I wont go back to the Alli pills due to the toilet problems.

Alli - side effects

September 28, 2008 by Anonymous, 1 year 9 weeks ago
Comment: 32170

I have been taking Alli for one week and have not exceeded the 15 grams of fat per meal (I am very careful not too) but I have persistent uncomfortable stomach/gastro issues such as gas (and yes, I am afraid to fart sometimes in case of the unwanted side effect, which I have not experienced as of yet).

Here is how I feel at every meal:
bloated/gassy
rumbling in my stomach/gastro area
foul smelling gas and bowel movements
heartburn and I have not heard anyone yet complain about that, but I am getting it and never have before???!

I am a 42 year old male, who is 6'2", 223lbs and lost about 7 pounds over a month ago and so tried to add this on to see if I could drop another 7 in the next month. I do excercise, which gets easier as you get thinner and will see this through a month to see if it makes a meaningful difference, if not, then I cannot put up with this discomfort. I believe in no pain no gain, so they should use the slogan pain = no gain (LOL). Trying to stay upbeat about losing weight and getting healthier.

Paul

Works Great!!!!!

February 18, 2008 by Anonymous, 1 year 40 weeks ago
Comment: 27620

I loooove ALLI. There are side effects. Loosing wieght takes time, hard work, and is not easy! Some people have a problem with this but I welcome small daily challenges like unwanted visitors like oils or even solids running down my leg. Its less painfull than running on the treadmill! Some people are afraid of people thinking they smell or are dirty (due to spotting through the paints/mini skirt) but I say your gross if your FAT!

Just Being Real,
Alex

Alli works! Yeap!

February 15, 2008 by Anonymous, 1 year 41 weeks ago
Comment: 27535

Alli works for me!!! As promised, I have lost a ib/week. It will only work if you commit to low fat cal reduced meals though. Good luck.

seems to work

October 29, 2007 by Jeremy W., 2 years 4 weeks ago
Comment: 25714

It works, at least in short-term.
As for long-term, well we have to wait to see

Weight Loss

July 30, 2007 by Amory - Chesapeake, VA (not verified), 2 years 17 weeks ago
Comment: 24391

I have been taking the alli pill for a month. I try and stay within the fat limitations, but sometimes cheat. I have lossed 16 pounds in one month. I get the side effects when I eat more than what is allowed on the fat intake. If you follow the fat intake you will lose weight and not have the side effects. That is just what I have had so far. I think this is a good healthy way to lose weight.

Oily spotting.

July 12, 2007 by Eric Kaufman (not verified), 2 years 20 weeks ago
Comment: 24198

I have been taking alli for about a week now. I have noticed a significant amount of the "oily spotting" as warned by the manufacturer. I even had a embarassing incident where the accumulated oil actually built up enough for a little to run
down my leg all the way to my sock. Unfortuantly I was wearing shorts that day :-(. My domestic partner also has been unable to tolerate sex lately, the oily fluids have a tendancy to cause his condom to break in less than a minute. If I don't start seeing results soon, I will discontiue use. Its side effects are just too drastic.

I have been taking it and it

July 8, 2007 by Anonymous (not verified), 2 years 20 weeks ago
Comment: 24165

I have been taking it and it has worked great for me so far.

While we're talking about diet pills and I'm tooting my horn...

June 17, 2007 by Rareearth42 (not verified), 2 years 23 weeks ago
Comment: 23990

No, I'm not "tooting" because I'm on Alli.

Following is another post from the old ARNA board on Yahoo, where I discussed the Acomplia results a year ago, in response to a skeptic about Lorcaserin. I think there are some much more effective diet drugs on the horizon.

"You're too pessimistic about ARNA. Everything is proceeding reasonably well, the only current delay is getting the OK from the FDA to move ahead with the APD125 phase 2. Lorcaserin is on track to start phase 3 this year, as are the two partnered programs, as is the anticoagulant program. Sanofi's rimonabant, the weight loss therapy that ought to pose the greatest competition to Lorcaserin, is held up at the FDA and my bet it's a safety issue, given all the publicity regarding Vioxx, Tysabri, and others. I think it's probably the depression signal seen in the the trials. Here's how I think about it....the THC in marijuana is a CB1 agonist, and causes euphoria (the "high") and the "munchies". Rimonabant is a CB1 antagonist and promotes less food intake (weight loss) and apparently depression in some sensitive individuals. In the recent, published study, there was a depression rate of 3% in the patients given 20 mg of rimonabant daily. I think that's too high to be acceptable, although it's possible it will eventually be marketed in the US with a black box warning. Other competition includes the companies developing PYY3-36, AMLN's Symlin + Leptin combination looks exciting in pre-clinical studies, and certainly others as well.

Regarding the current stock price, I'm not worried. The market moves up and down in the short term due to anxieties and enthusiasms of market timers and daytraders and institutions that have to show quarterly results, but long term changes are due to fundamentals and these are more predictable. .... If one were to buy and hold ARNA now, I am fairly confident it would be an excellent decision in the long term."

RE42

Orlistat xenical alli

June 17, 2007 by Rareearth42 (not verified), 2 years 23 weeks ago
Comment: 23989

BJS,

I've commented on the likelihood of success for an OTC lipase blocker previously....I think people will try it, indeed, a lot of people will try it. However few will stay on the drug because of the side effects. Following is a light-hearted, yet thus-far witheringly accurate commentary I posted on the Yahoo ARNA message board roughly a couple of years ago:

There's no question Xenical can effectively block fat absorption and lead to modest weight loss with long term use. The "but", however (note that I manfully resisted the extra "t"), is that the fat which isn't absorbed passes into the large intestine, where much of it, but not all of it, is cheerfully utilized by bacteria. The bacteria, in turn, make lots of gas. The end result of all this (har) is a lot of gas that smells like spoiled meat. Regular Xenical users are not welcome around the watercooler at work. Now, the stinky gas problem can be ameliorated somewhat with strict adherence to a very low fat diet, but if the patient could do that in the first place, they wouldn't need Xenical. So while there's no doubt OTC Xenical will eventually have some market share, it will be a small, outdoors market share......

RE42

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