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Although my response is not nearly as technical as the article or even the last user's comment, I have to say that I am hoping and praying that further research will explain why this drug stops working and how to implement a new drug or some other form of treatment. My Dad was diagnosed with Stage IV non-small cell lumg cancer back in 2003 and sadly passed away in June of 2008. With that said, I whole-heartedly attribute much of his "prolonged" life to Tarveva. He was on a clinical trial through Dana Farber in Boston, and with Tarceva, the tumors had shrunk to a "managable" size. He did have the rash/redness side effect, but to me he was able to walk me down the aisle and meet, know and love his two grandchildren when he orginally was given 18 months to live and survived 5-years. I just wish that Tarceva did not stop working and maybe I would have him here today.