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The note that stimulation of the dopamine receptors might also lead to impairment of the ACC was really interesting. I've done a lot of work with people struggling with opiate addiction and my initial reaction was that many addicts & alcoholics with a perfectly normally-functioning ACC may still choose to self-sabotage in the face of premonitions and early warnings. In fact, the premonitions and early warnings might be exactly what an addict would choose as a basis for further destruction. One of a number of treatments available (specifically, suboxone treatment) also works on the same dopamine receptors and neurotransmitters that might affect the ACC. Has any research been done to examine what effects such treatment might have on the ACC?