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But does it survive replication?
April 21, 2009
by Anonymous,
31 weeks 4 days ago
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Has anyone researched whether these methylated nucleotides survive replication? Do DNA polymerase complexes reliably replicate the exact methylated nucleotides or is *any* cytosine good enough?
It would be interesting to know whether a methylated nucleotide at a given locus is genetically persistent, or is its methylation an emergent property of the intracellular machinery, such that there are enzymes or RNA's floating around continually methylating nucleotides at particular sequences... I could see how either is possible, although frankly I'd find the latter more likely.
Alan