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First off, how can you tell if a mouse is depressed? or happy? When they don't make it through the maze and stop searching for that yellow piece of cheese at the end? I guess depressed mice, similar to depressed humans, give up and can't handle when life's challenges, as cruel as it may be at times. While yes, medicine, and gene alternation i suppose, can be good, what ever happened to just picking yourself up, brushing of the dust, and putting one foot in front of the other after you fall down. Is it really necessary, as pathetically as it sounds, to alter genetic make-up for people (or mice) to be happy?