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Combining Physics and Biology
April 11, 2006 by Richard G. Lanzara, 3 years 32 weeks ago
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You mention that "It may be time to take a step back from the details and try to see the big picture." See one attempt to understand the physicochemical basis for receptor activation at http://www.bio-balance.com/Ref.htm. Physicists may be particularly interested in the Weber's law article were a fundamental equation of equilibrium is derived and related to the responses of biological receptors through successive papers.
1. New Update - Molecular dynamics of a biophysical model for beta-2-adrenergic and G protein-coupled receptor activation J. Mol. Graphics Modell. in press.
2. Optimal Agonist/Antagonist Combinations Maintain Receptor Response by Preventing Rapid Beta-1 adrenergic Receptor Desensitization Intl. J. Pharmacol., 1(2): 122-131, 2005. pdf.
3. Activation of G Protein-Coupled Receptors Entails Cysteine Modulation of Agonist Binding, J. Molecular Structure (Theochem), 430/1-3: 57-71 (1998). pdf .
4. Weber's Law Modeled by the Mathematical Description of a Beam Balance, Mathematical Biosciences 122: 89-94 (1994). pdf .
-Richard G. Lanzara