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Inner workings of molecular thermostat point to pathways to fight diabetes, obesity

PHILADELPHIA -- Best known as the oxygen-carrying component of hemoglobin, the protein that makes blood red, heme also plays a role in chemical detoxification and energy metabolism within the cell. Heme levels are tightly maintained, and with good reason: Too little heme prevents cell growth and division; excessive amounts of heme are toxic.

Positive effects of high fruit and vegetable intake on cognitive performance in healthy people

September 9, 2009 by CarolynKay

CarolynKay's picture

Amsterdam - Researchers at the Institute of Biochemistry and Molecular Biology I of the Heinrich-Heine University, Düsseldorf, Germany, investigated the relationship between fruit and vegetable intake, plasma antioxidant micronutrient status and cognitive performance in healthy subjects aged 45 to 102 years. Their results, published in the August issue of the Journal of Alzheimer’s Disease, indicated higher cognitive performance in individuals with high daily intake of fruits and vegetables.

High fruit and vegetable intake positively correlated with antioxidant status, cognitive performance

Amsterdam, September 8, 2009 -- Researchers at the Institute of Biochemistry and Molecular Biology I of the Heinrich-Heine University, Düsseldorf, Germany, investigated the relationship between fruit and vegetable intake, plasma antioxidant micronutrient status and cognitive performance in healthy subjects aged 45 to 102 years.

Lapatinib shows minimal effect against liver cancer

PHILADELPHIA -- Use of the molecularly targeted agent lapatinib to delay tumor growth and improve the survival of patients with inoperable hepatocellular carcinoma, or liver cancer, only benefited certain subgroups of patients.

Autoimmune response can induce pancreatic tumor rejection

PHILADELPHIA -- Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research.

Prevent periodontitis to reduce the risk of head and neck cancer

PHILADELPHIA -- Chronic periodontitis, a form of gum disease, is an independent risk factor for head and neck squamous cell carcinoma. This suggests the need for increased efforts to prevent and treat periodontitis as a possible means to reduce the risk of this form of cancer.

Even in a safety net health system, colorectal cancer screening disparities remain

PHILADELPHIA -- Colorectal cancer screening rates are much lower among those in a safety net health system compared to the national average, and the number one predictor of screening is a combination of regular visits and insurance access.

Enzyme inhibitor takes an unexpected approach toward blocking cancer-promoting protein

Scientists at Fox Chase Cancer Center have discovered a unique method of attack that may be used to inhibit signaling enzymes called kinases, which often have a role in sustaining drug-resistant cancerous cells.

Pancreatic cancer affects blacks at higher rates

PHILADELPHIA -- Regardless of risk factors linked to pancreatic cancer, such as smoking and body mass index (BMI), blacks experienced higher rates of pancreatic cancer death than whites.

Weight gain in adulthood associated with prostate cancer risk; patterns differ by ethnicity

PHILADELPHIA -- Body mass in younger and older adulthood, and weight gain between these periods of life, may influence a man's risk for prostate cancer. This risk varies among different ethnic populations, according to results of a study in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research.

Scientists identify gene that predicts post-surgical survival from brain metastasis of breast cancer patients

PHILADELPHIA -- Researchers at the National Cancer Institute have identified a gene that may play a role in breast cancer metastasis to the brain, according to a report in Molecular Cancer Research, a journal of the American Association for Cancer Research.

Inhibition of NF-kappa B, a key inflammatory protein, reduced radiation toxicity in zebrafish

(PHILADELPHIA) Directly inhibiting the activity of a key protein mediator of inflammation reduced radiation toxicity in zebrafish embryos, and may ultimately be of help to patients receiving radiation therapy, according to researchers from the Kimmel Cancer Center at Jefferson.

Prodrug could help curb skin toxicity related to EGFR-inhibiting cancer drugs

(PHILADELPHIA) There may be a way around the harsh skin toxicity associated with a widely used cancer drug, according to a study published online this week in Cancer Biology and Therapy by researchers from City of Hope and the Kimmel Cancer at Jefferson.

Does the distance a patient has to travel affect where they choose to get their care?

PHILADELPHIA (August 28, 2009) -- Do patients choose where to get their care based on how long it takes to them to get there? Researchers at Fox Chase Cancer Center have recently documented a growing trend in the centralization of cancer surgery -- more patients seeking care at high volume centers, which are generally located in metropolitan areas.

Blood-flow metabolism mismatch predicts pancreatic tumor aggressiveness

PHILADELPHIA -- Researchers from Turku, Finland, have identified a blood-flow glucose consumption mismatch that predicted pancreatic tumor aggressiveness, according to results of a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.



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