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Researchers have discovered the mechanism by which human T-lymphotropic virus type 1 (HTLV-1), the virus which causes adult T-cell leukaemia, spreads through the body. Previously it was not understood how HTLV-1 was able to spread between cells and pass between individuals, but according to research published today in Science, the virus spreads by subverting normal T-cell (a type of immune cell) behaviour, and without needing to release virus particles.
The structure of a key energy-releasing enzyme found in all animals is designed to minimise free radical production, an international team of researchers has reported in the journal Science. In a startling feat of structural biology, the team visualised the entire molecular structure of succinate dehydrogenase in the bacterium E. coli, allowing them to see for the first time how the protein's three-dimensional shape helps prevent the formation of large quantities of these destructive oxygen atoms.
The results announced in the International Journal of Psychophysiology this month show a link between neurofeedback training and improved memory in a 40 person trial. Dr David Vernon, from Imperial College London at the Charing Cross hospital says: "Previous research has indicated that neurofeedback can be used to help treat a number of conditions including Attention Deficit Hyperactivity Disorder, epilepsy and alcoholism by training particular aspects of brain activity, but this is the first time we have shown a link between the use of neurofeedback, and improvements in memory." Neurofeedback is a learning procedure that has been involved in treatments enabling participants to normalize behaviour, stabilize mood and improve their cognitive performance. It works by allowing people to watch their brain activity, and through this, find a way to correct or improve it.
The discovery of 160 year old records in the archives of the Royal Society, London, has given scientists further evidence that Australian sea levels are rising. Observations taken at Tasmania's Port Arthur convict settlement 160 years ago by an amateur meteorologist have been compared with data from a modern tide gauge. "There is a rate of sea level rise of about 1mm a year, consistent with other Australian observations," says Dr David Pugh, from the UK's Southampton Oceanography Centre.
A golden early old age is within sight for many people, says new research funded by the Economic and Social Research Council, which demonstrates that the good life is much less influenced by your past ? the job your father had, for instance ? than by the present, when two of the most important influences are having choices about working or not working, and having friends in whom you can confide.
Scientists who built and will control the instruments to investigate plasma changes around a comet describe their contribution to the ten year long mission at a pre-launch press briefing in London today. While the actual launch date for the European Space Agency's Rosetta mission has yet to be confirmed, the scientists, engineers and technicians behind the plasma-detecting instruments on board the spacecraft are all ready to begin the journey to comet Wirtanen they hope will return a rich scientific bounty.
Researchers have discovered that melanopsin, a recently identified protein, plays a key role in a completely new light detection system in the eye. Professor Russell Foster, from Imperial College London at the Charing Cross Hospital comments: "It had long been assumed that the rod and cone cells of the retina are responsible for all light detection. However, over the last few years research from our group has led us to the inescapable conclusion that there is a third light detection system that has lain undiscovered over more than 100 years of intensive research on the eye. Although we have known of their existence for several years, it has proved difficult to discover much more about these new receptors".
The prospect of using bacteria to manufacture complex human proteins for use in therapeutic drugs is a step closer thanks to new research published today in Science. Researchers from Switzerland and the UK report they have engineered the bacterium Escherichia coli to carry a vital piece of cell machinery that adds sugar molecules to newly synthesized proteins by a process known as glycosylation. The finding opens up the possibility of producing complex human proteins such as Factor VIII and the hormone erythropoietin, which stimulates the production of red blood cells by stem cells in bone marrow. Both these proteins, which require the addition of sugar molecules to function properly, are currently produced by culturing mammalian cells, which can be a costly and technically difficult process.
Scientists have developed a rapid new blood test which may help predict the likelihood of a heart attack. The research published in Nature Medicine shows how a new science called Metabonomics can be used to test for coronary artery disease, using minimally invasive procedures. The test, which only needs a few drops of blood, measures the magnetic properties of molecules in blood using high frequency radio waves, which are then analysed using an advanced computer programme capable of detecting abnormal patterns of signals associated with heart disease.
Routine monitoring of volcanic activity on Jupiter's moon Io has turned up the largest eruption to date on Io's surface or in the solar system. The eruption took place in February 2001, though image analysis was only recently completed by a team of University of California, Berkeley, astronomers. Their results are published in the November issue of the planetary sciences journal Icarus. "The Surt eruption appears to cover an area of 1,900 square kilometers, which is larger than the city of Los Angeles and even larger than the entire city of London," said the lead researcher. "The total amount of energy being released by the eruption is amazingly high, with the thermal output from this one eruption almost matching the total amount of energy emitted by all of the rest of Io, other volcanoes included."
Listeria and certain strains of E. coli are the scourge of picnics, but researchers at Harvard Medical School and London's Hammersmith Hospital show in the November Gene Therapy that combining bacterial components of these bad bugs can create a powerful vector against melanoma challenged mice.
Paper wasps all look the same, right? An animal behaviorist at Cornell University reports that the wasp's black-and-yellow uniform is not uniform at all. One wasp, she has discovered, can recognize another through facial and abdominal markings, all but displacing the scientific dogma that insects carry out identification and communication only by employing chemicals called pheromones. "Their faces are far more beautiful and different than you'd expect," says Elizabeth Tibbetts.
An international research consortium has launched an approximately $100 million public-private effort to create the next generation map of the human genome. Called the International HapMap Project, the new venture is aimed at speeding the discovery of genes related to common illnesses such as asthma, cancer, diabetes and heart disease.
