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University of Minnesota invention will help speed development of drug treatments for heart failure

November 23, 2009

Research conducted by University of Minnesota scientists, in collaboration with Celladon Corporation, has led to the invention of technology to more rapidly identify compounds for the treatment of heart failure.

Scripps research scientists find new link between insulin and core body temperature

November 19, 2009

LA JOLLA, CA -- November 19, 2009 ?A team led by scientists at The Scripps Research Institute have discovered a direct link between insulin -- a hormone long associated with metabolism and metabolic disorders such as diabetes -- and core body temperature.

Research reveals lipids' unexpected role in triggering death of brain cells

November 12, 2009

The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St.

Novel mouse gene reduces major pathologies associated with Alzheimer's disease

November 11, 2009

A new study reveals that a previously undiscovered mouse gene reduces the two major pathological perturbations commonly associated with Alzheimer's disease (AD).

Scripps team shows diet switching can activate brain's stress system, lead to 'withdrawal' symptoms

November 10, 2009

LA JOLLA, CA, November 9, 2009 - In research that sheds light on the perils of yo-yo dieting and repeated bouts of sugar-bingeing, researchers from The Scripps Research Institute have shown in ani

Remotely operated vehicles and satellite tags aid turtle studies

October 28, 2009

Researchers are using a remotely operated vehicle (ROV) and satellite-linked data loggers to learn more about turtle behavior in commercial fishing areas and to develop new ways to avoid catching t

AGU Journal highlights -- Oct. 26, 2009

October 26, 2009

The following highlights summarize research papers that have been published or accepted for publication (paper in press) in Geophysical Research Letters (GRL).

Team led by Scripps Research and UC San Diego scientists reveals secrets of drought resistance

October 22, 2009

La Jolla, CA, October 21, 2009 -- A team of biologists in California led by researchers at The Scripps Research Institute and the University of California (UC), San Diego has solved the structure of a critical molecule that helps plants survive during droughts.

Fate Therapeutics announces creation of small molecule platform for commercial-scale reprogramming

October 18, 2009

La Jolla, CA -- October 18, 2009 -- Fate Therapeutics, Inc. announced today the generation of human induced-pluripotent stem cells (iPSCs) using a combination of small molecules that significantly improves the speed and efficiency of reprogramming. The discoveries, which were made by Sheng Ding, Ph.D.

A major step in making better stem cells from adult tissue

October 18, 2009

LA JOLLA, CA -- October 15, 2009 A team led by scientists from The Scripps Research Institute has developed a method that dramatically improves the efficiency of creating stem cells from human adult tissue, without the use of embryonic cells. The research makes great strides in addressing a major practical challenge in the development of stem-cell-based medicine.

What drives our genes? Salk researchers map the first complete human epigenome

October 14, 2009

LA JOLLA, CA -- Although the human genome sequence faithfully lists (almost) every single DNA base of the roughly 3 billion bases that make up a human genome, it doesn't tell biologists much about how its function is regulated.

Genetics of patterning the cerebral cortex

October 13, 2009

LA JOLLA, CA -- The cerebral cortex, the largest and most complex component of the brain, is unique to mammals and alone has evolved human specializations. Although at first all stem cells in charge of building the cerebral cortex -- the outermost layer of neurons commonly referred to as gray matter -- are created equal, soon they irrevocably commit to forming specific cortical regions.

It's in the bank: Human cord blood reprogrammed into embryonic-like stem cells

October 1, 2009

Human umbilical cord blood cells may be far more versatile than previous research has indicated. Two independent studies, published by Cell Press in the October 2nd issue of the journal Cell Stem Cell, report that they have successfully reprogrammed human umbilical cord blood cells into cells with properties similar to human embryonic stem cells.

Umbilical cord blood as a readily available source for off-the-shelf, patient-specific stem cells

October 1, 2009

LA JOLLA, CA -- Umbilical cord blood cells can successfully be reprogrammed to function like embryonic stem cells, setting the basis for the creation of a comprehensive bank of tissue-matched, cord blood-derived induced pluripotent stem (iPS) cells for off-the-shelf applications, report researchers at the Salk Institute for Biological Studies and the Center for Regenerative Medicine in Barcelon

Scripps research scientists find missing puzzle piece of powerful DNA repair complex

October 1, 2009

LA JOLLA, CA -- September 30, 2009 ?Researchers at The Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy.

The research was published in the October 2, 2009 issue of the journal Cell.



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