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NIAID set to launch clinical trials to test 2009 H1N1 influenza vaccine candidates

Scientists in a network of medical research institutions across the United States are set to begin a series of clinical trials to gather critical data about influenza vaccines, including two candidate H1N1 flu vaccines. The research will be under the direction of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

Scientists link immune system's natural killer cells to infant liver disease

CINCINNATI -- Scientists have linked an overactive response by one of the immune system's key weapons against infection -- natural killer, or NK, cells -- to the onset of biliary atresia in infants, a disease where blocked bile ducts can cause severe liver damage and death.

Discovery of genetic toggle switch inches closer to possible diabetes cure

CINCINNATI - Scientists have identified a master regulator gene for early embryonic development of the pancreas and other organs, putting researchers closer to coaxing stem cells into pancreatic cells as a possible cure for type1 diabetes.

Researchers at Cincinnati Children's Hospital Medical Center report their findings in the July 21 Developmental Cell.

Novel gene found for dilated cardiomyopathy

Researchers in the Heart Institute at Cincinnati Children's Hospital Medical Center have discovered a novel gene responsible for heart muscle disease and chronic heart failure in some children and adults with dilated cardiomyopathy (DCM).

Gene expression findings a step toward better classification and treatment of juvenile arthritis

Scientists have discovered gene expression differences that could lead to better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA).

Inhaled growth hormone safe for children deficient in this key protein

INDIANAPOLIS -- A multi-center clinical trial led by a Riley Hospital for Children endocrinologist has found that inhaled growth hormone (GH) is well tolerated by children with GH deficiency and that this easy-to-use method can, over a one-week period, safely deliver GH to the blood stream.

Scientists identify gene vital to early embryonic cells forming a normal heart and skull

New research from Cincinnati Children's Hospital Medical Center highlights the critical role a certain gene and its protein play during early embryonic development on formation of a normal heart and skull.

Major breakthrough in early detection and prevention of AMD

LEXINGTON, Ky. (June 15, 2009) -- A team of researchers led by Dr. Jayakrishna Ambati at the University of Kentucky has discovered a biological marker for neovascular age-related macular degeneration (AMD), the leading cause of blindness in older adults.

BPA may cause heart disease in women, research shows

CINCINNATI -- New research by a team of scientists at the University of Cincinnati (UC) shows that bisphenol A (BPA) may be harmful for the heart, particularly in women.

Results of several studies are being presented in Washington, D.C., at ENDO 09, the Endocrine Society's annual meeting, June 10-13.

Fatty foods -- not empty stomach -- fire up hunger hormone

CINCINNATI -- New research led by the University of Cincinnati (UC) suggests that the hunger hormone ghrelin is activated by fats from the foods we eat -- not those made in the body -- in order to optimize nutrient metabolism and promote the storage of body fat.

Protein may be strongest indicator of rare lung disease, study shows

CINCINNATI -- Researchers at the University of Cincinnati (UC) have discovered a protein in the lungs that can help in determining progression of the rare lung disease Idiopathic Pulmonary Fibrosis (IPF).

University of Cincinnati study finds needle biopsies safe in 'eloquent' areas of brain

CINCINNATI -- After a review of 284 cases, specialists at the Brain Tumor Center at the University of Cincinnati (UC) Neuroscience Institute have concluded that performing a stereotactic needle biopsy in an area of the brain associated with language or other important functions carries no greater risk than a similar biopsy in a less critical area of the brain.

Inflammatory bowel disease on the rise in specific populations

CHICAGO, IL (June 1, 2009) -- Researchers are making great strides in understanding the development and treatment of inflammatory bowel disease, a chronic inflammatory condition of the digestive tract that affects more than a half million Americans, according to several studies being presented at Digestive Disease Week® 2009 (DDW®).

Telemedicine may improve care for school children with diabetes

Cincinnati, OH, May 21, 2009 -- Type 1 diabetes is the most common chronic childhood disease. The management of this serious medical condition includes regular fingerstick glucose measurements, multiple daily injections of insulin, and frequent insulin dose adjustments.

Transplant patients have worse cancer outcomes, analysis shows

CINCINNATI--After comparing two patient cancer registries--one featuring transplant patients and the other the general population--researchers at the University of Cincinnati (UC) have found that transplant patients experience worse outcomes from cancer.

These results will be published in the May 15, 2009, edition of the journal Transplantation, which is currently in press.



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