Understanding TH9507 in people affected with HIV lipodystrophy
September 2, 2008 by Eugene Jacquescoley
HIV prevalence in the U.S. was 24% to 27% or 1,039,000 to 1,185,000 people (Centers for Disease Control, 2003). Within this population, the prevalence of HIV lipodystrophy was 2% to 60% of all patients who were HIV positive in 2007 (Robles et al, 2007). As protease inhibitors have a realized association with longevity in HIV patients, lipodystrophy is also getting a second look from the clinical and pharmaceutical communities. Refer to an excerpt from a case presentation of a 39y.o. Asian male who was initially diagnosed with AIDS and presently has a diagnosis of HIV lipodystrophy. “My doctors told me that a new drug, [indinavir], had been released. But I had to apply for that through a mail lottery system because it was not yet available on the market. I was accepted into the trial, and that is when my history of lipodystrophy started. It was a gradual change, and by the second year of being on [indinavir], I began to see the effects. I noticed that under my chin, I started getting fat retention, and my cheeks were becoming a bit sunken (Robles et al, 2007).”
Thousands of HIV patients have similar stories with regards to their body morphology. Whether attributed to lipathophy (localized loss of fat tissue) as described by Dr. Robles patient or lipohypertrophy (abnormal central fat accumulation) which has similar prevalence patterns. TH9507 a growth hormone promoter may show promise in reducing the symptoms associated with lipodystrophy in the near future.
Lipodystrophy, also called fat redistribution syndrome, is a condition that often occurs in HIV-positive people and is characterized by changes in body shape and metabolism. Body shape changes may include the accumulation and/or loss of fat, which can affect appearance. Metabolic changes may include increased resistance to insulin and abnormally high levels of blood cholesterol and triglycerides. These do not all necessarily occur together; each may occur separately or in any combination. Even though it is not clear what the etiology of lipodystrophy; there is a renewed interest in collecting data and making useful observations.
The endocrinology community seems to agree that there may a correlation with protease inhibitor therapy (the subsequent line of FDA approved ant-HIV medications) and nucleoside reverse transcriptase inhibitors (first class of drugs approved by the FDA). Based upon preliminary research that claims to understand the “mechanism of action” causing lipodystrophy o fat redistribution. Other observations have comprised, duration of both total and NRTI therapy, insulin resistance and HIV disease itself.
According to the New England Journal of Medicine (Falutz et al, 2007; 2008) Canadian researchers assessed the use of tesamorelin to decrease visceral adiposity. From a random group of 412 patients with HIV (86% of whom were men) and had a subsequent diagnosis of lipodystrophy: received 2mg [subcutaneously] of tesamorelin or placebo for 26 weeks. Moreover, computed tomography was utilized to establish a baseline for all participants of visceral adipose tissue.
“The accumulation of adipose tissue predominantly in the visceral depot plays a major role in the development of the metabolic and cardiovascular complications of obesity. In adults, intra-abdominal adipose tissue has emerged as a clinically relevant type of body fat independent of total body fat. Therefore, estimating visceral fat accumulation is important for evaluating patients at risk of cardiovascular disease (Osei-Assibey, O. and Kumar, S.).” Furthermore, authors have also indicated that body mass index (BMI) may fall short in considering the body’s proportional composition. This rationale validates (Faultz et al, 2007) utilization of computed tomography when establishing a baseline.
During Phase III of the clinical trial, tesamorelin proved to be well tolerated and reduced visceral adipose tissue by 15% for those who received the drug during the 26 weeks. This is compared to the placebo and a 5% increase in visceral adipose tissue. According to the Food and Drug Administration (FDA) no drugs have been approved for the management of visceral adipose tissue in HIV. The FDA’s decision not to approve TH9507 may depend on the notable side effects, including fluid retention and increase blood glucose elevations.
Researchers at Theratechnologies, a Canadian biopharmaceutical company have discovered novel therapeutic products for commercialization. According to Theretechnologies, Tesamorelin (TH9507) has a potential market to 2 million HIV patients in North America and forecast efforts reveal that approximately 400,000 patients with HIV are being treated for HIV lipodystrophy. Theratechnologies has clearly identified a need for a unique population and as obesity trends upwards in the U.S., it seems prudent that the FDA should revisit this experimental regimen in the near future.
References
Nicholson, M. (2004). Diet and Lipodystrophy. Retrieved from http://www.thebody.com/content/art1032.html on September 2, 2008.
Robles, D., Olson, J. and Colven, R. (2008). Lipodystrophy, HIV. Diseases of the Subcutaneous Tissue. Retrieved from http://www.emedicine.com/derm/topic877.htm on September 2, 2008.
Centers for Disease Control and Prevention. [Online]. HIV/AIDS. Retrieved from http://www.cdc.gov/hiv/ on September 2, 2008.
Falutz, J. Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., Berger, D., Brown, S. Richmond, G., Fessel, J., Turner, S., and Grinspoon, S. Metabolic effects of a growth hormone-releasing factor in patients with HIV. New England Journal of Medicine, 2007 (23):2397-2399.
Libman, H. (2008). A 39-Year Old Man with HIV-Associated Lipodystrophy. Retrieved from http://jama.ama-assn.org/cgi/content/full/300.5.jrr80007 on September 2, 2008.
Osei-Assibey, G. and Kumar, S. [Online]. Assessment of visceral adiposity: tape measure to MRI. Retrieved from http://www.d4pro.com/idm/site/assessment on September 2, 2008.
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CURE for HIV/AIDS....Ambush
December 8, 2008 by Anonymous, 50 weeks 6 days ago
Comment: 33259
THE CURE for HIV/AIDS.......AMBUSH
THE IDEA that AMBUSH cures AIDS
is being proven by the more than 400 individuals who have taken a dose of 60 ml three times daily for 21 days. The result is that AMBUSH 'KILLS' the virus by causing the protein envelope to rupture and the viral particles are discarded by the white blood cells. AMBUSH is able to 'KILL' the virus that are 'hiding' in the lymph system by its 'natural radioactive' properties. This process allows the body to 'return to normal health' with a corresponding immunity to that or those strains of the virus.
What is AMBUSH ?
AMBUSH is a radioactive isotope of uranium that is found in the 'palm' plant of which there are more than 3000 species. When ingested, AMBUSH causes the body temperature in the trunk area to rise to about 102 degrees when the individual is sleeping. The preparation takes four hours per batch, which is then given to the individuals for consumption 60 ml three times daily for 21 days. AMBUSH is a herbal preparation in this form but it contains an active ingredient which is a 'NEW' crystalline substance, a drug from the 'palm plant' similarly to ASPIRIN originating from the willow tree bark
RESULTS:
After 21 days on AMBUSH, ALL the individuals experienced a decrease in viral load to undetectable, an increase in cd4, increase in RBC, an improvement in general health such as more color to the face, decrease in Buffalo hump, an increase in gluteal muscles, a decrease to having no joint pains whereby individuals can bend to touch their toes, and walk up steps are but a few examples. There is also a dramatic increase in their sexual appetite beginning after the first week of therapy
DISCUSSION:
In any plant concoction such as percolated 'tea', there are 30-40,000 compounds, whi ch would take the scientific community twenty years to isolate one particular ingredient if they knew what they were looking for. The LORD GOD has given me seven steps to isolate the active ingredient, which is soft and metallic in nature and has a carbon- uranium-sulfur-(classified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure.
As an antiviral and 'natural radioactivity' producing agent, AMBUSH is also effective against leukemia, lupus and HPV. Here I am saying that I have 'GIVEN' AMBUSH in the same 'strength' and dosage to patients with leukemia, lupus and HPV. A 35 year old male with HIV found it difficult to impossible to urinate was put on 'green tea' and water while the doctors contemplated prostrate surgery. One of the doctors gave him my number , I sent him a supply of AMBUSH an d he has not been given any more ARV's, since taking AMBUSH 18 months ago, is in 'good' health and has expressed a willingness to be examined by HIV investigators like many others who have taken AMBUSH.
I have sent this 'IDEA' to most HIV research agencies, scientist of the field, universities, hospitals, clinics, politicians and news agencies to which it is REJECTED because the name of THE LORD GOD is mentioned. He has steered me scientifically through the processes such as which plant and how to produce the active ingredient. What are the odds of a Florida Pharmacist picking a plant would contain the CURE for HIV/AIDS ?
I have never charged any of the people for their supply of AMBUSH but a life saving has been spent on the project with NO renumeration from any sources because AMBUSH falls outside the walls of modern medicine and research.
PROPOSAL:
My proposal is that I PROVE that AMBUSH CURES HIV/AIDS by giving it to a number of END-STAGE or DRUG-RESISTANT people and the scientific community watches their recovery. This proposal addresses the problem in that I have already outlaid the results to be obtained.
This IDEA is unconventional in that the scientific community has rejected AMBUSH because I say it is GOD given. Secondly if I wrote it according to certain standards, then it might be peer reviewed. However, THE LORD GOD has also shown me that there are five enzyme systems associated with the virus, reverse transcriptase, protease, fusion and two more of which causes the virus to be AIRBOURNE. This means that without DIVINE intervention mankind and ALL warm- blooded mammals will be extinct in a number of years.
The PROOF of what I am saying is found in scientific papers wherein it is found that when the protease cuts the viral strands, it cuts it at DIFFERENT lengths EVERY time, to which it should always be a valine at the end but is a different amino acid every time. This is why it is IMPOSSIBLE to produce a VACCINE.
Since this is NOT a hypothesis but there are about 400 individuals who have taken AMBUSH, here lies a vast area in which to check, recheck and confirm that AMBUSH CURES AIDS. Let it be mentioned that during the HIV reproductive cycle, reverse transcriptase converts viral RNA into DNA compatible to human genetic materials. Thus the human DNA has been 'hijacked' and since each person has a DIFFERENT DNA, then the new viral copy is unique to that person which shows that each individual has a DIFFERENT STRAIN of the virus. Consider two HIV positive people swapping viral strains and increasing its complexity with multiple partners.
It can also be proposed that they be revisited as proof that the strain or strains that they had were 'killed' at the time of taking AMBUSH considering that a person can catch as many different strains as there are people who are infected by HIV.
I am also willing to work with the scientific community in identifying those individuals who took AMBUSH and wish to be identified with this process notwithstanding that some are stigmatized while others are jubilant,
Once AMBUSH is verified as being able to accomplish that which is aforementioned then the next stage might be the natural and artificial synthesis of the substance.
Finally, if this is accepted or not, believed or not, THE LORD GOD always wins and this is the heavenly truth to which AMBUSH was divinely given to mankind for the CURE of HIV/AIDS and it will be here forever. Apostle Shada Mishe.
apostleshadamishe@gmail.com
Here is a video taped presentation that I gave at t he Martin Luther King library in Washington
http://www.youtube.com/watch?v=8V53D1w__Po
http://www.youtube.com/watch?v=vPwuwlVBOV0
http://www.youtube.com/watch?v=ZejptOwMTzQ
http://www.youtube.com/watch?v=CqcTgIAhrhc
http://www.youtube.com/watch?v=f7HPKcT_iwY
http://www.youtube.com/watch?v=W9iQfgiYAnw
http://www.youtube.com/watch?v=i3RzRS6tJDM